Ridge Preservation Using Guided Regenaration, Platelet-rich Plasma and Free Gingival Grafts

The goal of this clinical trial is to learn if ridge preservation methods with dense polytetrafluoroethylene membranes, with d-PTFE membranes and platelet-rich plasma, and with free gingival grafts can reduce vertical resorption of the post-extraction socket walls.

Researchers compared each experimental group to a control group (unassisted socket healing). Participants were randomly allocated to one of the four groups.

Cone-beam computed tomography was performed after the procedure and 3 months post-operatively to evaluate the vertical socket wall resorption.

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Key information

Conditions

Post-Extraction Socket Healing Ridge Preservation

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical University Varna

Varna, 9002, Bulgaria

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients in the age group 18-65 years;
Patients in good general condition;
Patients requiring extraction of premolars or molars;
Patients in whom restoration of the missing tooth with a dental implant and/or prosthetic construction is planned;
Signed informed consent to participate in the study.

Exclusion criteria

Patients with contraindications for general surgical treatment:

patients with uncontrolled arterial hypertension;
patients with uncontrolled metabolic diseases;
patients with AMI in the last 6 months;
patients on hemodialysis treatment;
patients who underwent chemotherapy and/or radiotherapy in the last year;
patients on immunosuppressive therapy;
patients on anti-resorptive and anti-angiogenic therapy;
patients with concomitant acute diseases at the time of the study;
patients with proven psychiatric diseases;
pregnancy.
There are local contraindications:

insufficient volume of bone after the extraction to carry out RP;
acute inflammatory disease or tumor process in the area;
Lack of informed consent.
Lack of patient motivation for the treatment.

Treatment and study plan

Ridge preservation technique

Procedure

Tooth extraction, deperiostation of the buccal and oral marginal gingiva, placement of d-PTFE membranes and suturing.

Other names: ridge preservation, socket preservation

Ridge Preservation

Procedure

Tooth extraction, socket filling with PRP, deperiostation of the buccal and oral marginal gingiva, placement of d-PTFE membranes and suturing.

Other names: socket preservation

Primary outcomes

Vertical post-extraction resorption of the socket walls

Time frame: 3 months

Each socket wall is measured using CBCT right after the extraction and after 3 months to assess the vertical resorption.

Sponsors and collaborators

Lead sponsor

Medical University of Varna

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2023
Study completion: 2023
First posted: Oct 1, 2024
Registry last updated: Oct 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed