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Completed

NCT Number: NCT01976039

Rhinopharyngeal Retrograde Clearance is Effective to Adequate Upper Airways Function in Adults

Professionals working in polluted areas may present increased clinical airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and bronchiolitis, and instillation the nasal cavity with saline has been used to reduce nasal inflammation in rhinitis and sinusopathies. The aim of this study was to assess the effects of RRC and RCC combined with saline (RRC+S) on nasal mucociliary clearance (MCC), mucus surface property, cellularity and airways symptoms in professional motorcyclists.

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Key information

Conditions

Nasal Obstruction Airway Obstruction Exposure to Pollution Nose Diseases Otorhinolaryngologic Diseases Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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About this study

Male motorcyclists (mean age 36 years) were recruited and randomly assigned to RRC or RRC+S. Subjects were assessed at baseline and 15 days after interventions for saccharin test, mucus contact angle, cellularity in nasal lavage and airways symptoms with the use of SNOT-20 questionnaire. Data were analyzed by two-way ANOVA for repeated measures with Bonferroni´s correction. A passive monitoring-system of nitrogen dioxide was used to assess the individual air pollution exposure along the study period. The association between nitrogen dioxide and the airways outcomes was analyzed by Spearman correlation test.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Professional motorcyclists aged 18 years to 45 years
  • Minimum of one year in that occupation
  • Agreement with the written informed consent

Exclusion criteria

  • Smokers
  • Inability to understand and to follow commands
  • Previous nasal surgery
  • Respiratory infection in the previous 30 days

Treatment and study plan

rhinopharyngeal retrograde clearance (RRC)

Other

The rhinopharyngeal retrograde clearance is a respiratory physical therapy technique that uses a forced inspiratory maneuver to clear the nasopharynx with the aid of saline instillation

Other names: RCC+S

Primary outcomes

  1. Saccharine transit time test (STT)

    Time frame: 15 days

    To measure nasal mucociliary clearance. Subjects were asked to report the first perception of a sweet taste after 25 mg of saccharine powder was deposited in the free airflow nostril.

Secondary outcomes

  1. mucus surface property

    Time frame: 15 days

    The contact angle of nasal mucus was measured.

Other outcomes

  1. SNOT-20

    Time frame: 15 days

    A questionnaire to assess the symptoms of the nose and airways for rhinosinusitis

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Collaborators

  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Official study title

The Effectiveness of Rhinopharyngeal Retrograde Clearance on the Upper Airways Symptomatology and Function in Adults

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Nov 5, 2013
Registry last updated
Apr 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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