RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect

Periodontal regeneration is a complex process that involves coordinated activities and interactions of many cell types, extracellular matrix, cytokines, and specific growth factors to restore tissue integrity. The most important challenge facing periodontal regeneration is cellular insufficiency. Periodontal defects usually have a limited regenerative capacity due to their bounded surface area which is supposed to provide the wound area with a limited number of viable cells and a limited amount of biologic mediators. Cell recruitment and adhesion into the defect area are essential for cells to survive and secrete collagen.

Apoptosis is initiated when failure in adhesion in many different cell types occurs. Some periodontal treatment options failed in the reconstruction of the defect due to failure in wound stabilization and subsequent cell adhesion. Many treatment options have been developed to enhance defect stability and cellular recruitment including the use of GTM and different biologics. However, the treatment outcomes vary considerably depending on the level of the defect cellularity and the degree of cell recruitment into the defect area. For maximum outcomes, enhanced stability, vascularity, and biologics-sustained delivery were suggested. The minimally invasive surgical technique (MIST) suggested by Cortellini et al. offers a suitable level of tissue preservation that could help in defect stability and cellular adhesion. It was suggested to promote flap stability, maintain space, and maintain a greater amount of blood supply at the alveolar crest and papillary levels.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Intrabony Defect Alveolar Bone Loss Bone Diseases Bone Resorption Mouth Diseases Musculoskeletal Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Periodontitis is an inflammatory multifactorial disease initiated by pathogenic bacteria accumulated as a biofilm on the tooth surface leading to clinical attachment loss (CAL), pocket formation (PD), bleeding on probing (BOP), and bone loss which if neglected may lead to increased tooth mobility and final tooth loss. Pathological tooth mobility may arise from extensive alveolar bone loss, traumatic occlusion, acute periodontal inflammation, and apical tooth displacement. Treating tooth mobility can be a challenging process, particularly for patients with severe periodontitis, including those in stage III or IV, who often experience a range of these symptoms. ue to compromised periodontal support. Therefore, effective treatment not only relies on periodontal therapy but also on occlusal stability and tooth splinting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• All patients included will have moderate to advanced periodontitis.

Patients included in this study will be free from any systemic diseases according to criteria of Modified Cornell Medical Index(10).
Patients who had not undergone any type of regenerative periodontal therapy six months prior to the initial examination.

Exclusion criteria

• Patients with systemic diseases, smokers, pregnant (female).

Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.

Treatment and study plan

RGD Peptide

Drug

RGD peptide is an integrin binding site

Primary outcomes

CAL by millimeters

Time frame: baseline, 3months and 6 months

Measure clinical attachment loss pre and after-intervention

Study contacts

Contact information is provided by the study sponsor or research team.

shaimaa Hamdy, lecturer of Periodontology

CONTACT

[email protected]

+201030576405 ext. +201555035523

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Official study title

The Use of Integrin Binding Domain Loaded Hydrogel (RGD) With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect (Randomized Clinical Trial Study)

Acronym: MINST + RGD

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Apr 20, 2025
Registry last updated: Apr 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting