Resveratrol Supplementation on Exercise in Healthy Sedentary Adults

Inclusion criteria

• between the age of 18-65 years
• healthy, sedentary as per CDC (Less than 150 minutes of moderate activity[brisk walking] or less than 75 minutes of strenuous activity [jogging] on a typical week)
• not planning a significant change in their level of physical activity during the study period
• have a body mass index (BMI) between 20 and 30
• give informed consent and be willing to comply with protocol requirements

Exclusion criteria

• have heart disease, lung disease, and liver disease
• be unable to perform maximal exercise on a cycle ergometer ("maximal" defined by attainment of peak heart rate or ventilation within 15% of the predicted maximum or a respiratory quotient of > 1.15). It should be noted that maximal does not imply normal aerobic capacity
• use medications that may affect exercise performance ( β-blockers, Ca channel blockers
• be a smoker or have a past history of smoking more than total 5 pkg/year
• be pregnant or lactating
• use oral contraceptives
• have severe or unstable medical illness
• have blood/urine screening test results outside of the normal reference range and deemed clinically significant by the clinical investigator. Note: only minor variations in screening results outside of the normal references ranges will be permitted.
• take an anticoagulant, antiplatelet, NSAID, antidiabetic, antihypertensive, estrogen, SERM, immunosuppressant, vasodilator drug; or a significant medication metabolized via cytochrome P450 enzymes
• have current or history of a hormonal disorder, including cancer
• have a bleeding disorder, autoimmune condition
• have allergies to any of the ingredients in the study product or placebo
• have thrombosis of lower extremities
• have electrolyte abnormalities
• have recent myocardial infarction (i.e. within one year or less)
• have unstable angina
• have uncontrolled arrhythmia's causing symptoms or haemodynamic compromise
• have active endocarditis
• have acute myocarditis or pericarditis
• have symptomatic severe aortic stenosis
• have uncontrolled heart failure
• have acute non-cardiac disorder that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis)
• have a left main coronary stenosis or its equivalent
• have moderate stenotic valvular heart disease
• have severe untreated arterial hypertension (>200 mmHg systolic, >120 mmHg diastolic)
• have significant pulmonary hypertension
• have tachyarrhythmias or bradyarrhythmias
• have hypertrophic cardiomyopathy
• have mental impairment leading to inability to cooperate
• have high-degree atrioventricular block
• have cardiac (bradyarrhythmias, ventricular tachycardia, myocardial infarction, heart failure, hypotension, and shock) and non-cardiac (musculoskeletal trauma, severe fatigue, dizziness, fainting, body aches) complications.
• have kidney disease
• have excessive vomiting
• be dehydrated