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Completed

NCT Number: NCT03898206

Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults

The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart disease. This study will compare these responses in normal-weight versus overweight/obese South Asian adults.

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Key information

Conditions

Cardiovascular Risk Factor Behavior Cardiovascular Diseases Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Motor Activity Nutritional and Metabolic Diseases Physical Activity Sedentary Behavior Sedentary Lifestyle

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Bedfordshire

Bedford, Bedfordshire, MK41 9EA, United Kingdom

About this study

Participants will attend a preliminary testing session where height, weight, body fat and waist circumference will be measured. They will be familiarised with a motorised treadmill that will be used during the experimental visit below and will take part in an exercise test to determine a light-intensity walking speed for the experimental visit.

Participants will then attend two experimental visits in a random order:

  • Prolonged sitting (SIT): Participants will remain seated for 5 hours and instructed to reduce excessive movement.
  • Breaking up sitting with walking breaks (INT-SIT): Participants will rise from the seated position every 30 minutes throughout the experimental period to walk on a motorised treadmill at a light intensity for 5 minutes. After performing walking activity, they will return to the seated position. In addition, blood sample will be taken at the resting position just before each physical activity bout. The activity breaks will be undertaken on 9 occasions, providing a total of 45 min of light-intensity activity.

During each visit, blood pressure will be taken 11 times and blood samples will be taken 10 times. Participants will be given a breakfast and lunch meal to consume.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Self-identified South Asian ethnicity.
  • Self-report sitting at least 7 hours per day.
  • Normal weight, overweight or obese.

Exclusion criteria

  • Unable to speak and read English.
  • Contraindications to performing light-intensity walking.
  • Diagnosed cardiovascular disease or diabetes.

Treatment and study plan

Breaking up sitting with walking breaks (INT-SIT)

Other

See Breaking up sitting with walking breaks arm description

Prolonged sitting (SIT)

Other

See Prolonged sitting arm description

Primary outcomes

  1. Postprandial Glucose

    Time frame: Measured over the 5 hour condition period

    Incremental area under the curve for each 5 h condition will be calculated for glucose

Secondary outcomes

  1. Postprandial Triglycerides

    Time frame: Measured over the 5 hour condition period

    Incremental area under the curve for each 5 h condition will be calculated for triglycerides

  2. Postprandial Insulin

    Time frame: Measured over the 5 hour condition period

    Incremental area under the curve for each 5 h condition will be calculated for insulin

  3. Metabolic Load Index

    Time frame: Measured over the 5 hour condition period

    Incremental area under the curve for each 5 h condition will be calculated for the Metabolic Load Index (MLI).

    The MLI will be calculated using the following equation:

    MLI (mmol.L-1) = blood glucose (mmol.L-1) + TAG (mmol.L-1). Lower values of MLI are considered better for cardiometabolic health!

  4. Resting Energy Expenditure

    Time frame: Measured for the 5 hour condition period

    Incremental area under the curve for each 5 h condition will be calculated for resting energy expenditure

  5. Resting Fat Oxidation

    Time frame: Measured for the 5 hour condition period

    Incremental area under the curve for each 5 h condition will be calculated for resting fat oxidation

  6. Resting Carbohydrate Oxidation

    Time frame: Measured for the 5 hour condition period

    Incremental area under the curve for each 5 h condition will be calculated for resting carbohydrate oxidation

  7. Mean Arterial Pressure

    Time frame: Measured over the 5 hour condition period

    Mean Arterial Pressure (MAP) over the 5 h conditions.

    The following formula will be used to calculate MAP, where P is blood pressure (systolic or diastolic):

    MAP = PDiastolic + 1/3 (PSystolic - PDiastolic).

  8. Heart Rate

    Time frame: Measured over the 5 hour condition period

    Mean heart rate over the 5 h conditions

Sponsors and collaborators

Lead sponsor

University of Bedfordshire

Other

Collaborators

  • Brunel University

Registry information

Official study title

Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in Normal Weight Versus Overweight and Obese South Asian Adults

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Apr 1, 2019
Registry last updated
Apr 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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