Resveratrol and Serum Apo A-I

Inclusion criteria

• aged between 45 and 70 years
• HDL-C <1.0 mmol/L (men)
• HDL-C <1.3 mmol/L (women)
• serum total cholesterol <8.0 mmol/L
• plasma glucose <7.0 mmol/L
• BMI between 25 - 35 kg/m2
• non-smoking
• willingness to abstain from resveratrol rich products from two weeks prior to the study and the duration of the study:

• grapes and grape juice
• wine (red and white)
• all berries
• peanuts
• peanut butter
• soy (products)
• pomegranate

Exclusion criteria

• unstable body weight (weight gain or loss >3 kg in the past 3 months)
• indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus
• use of medication or a medically-prescribed diet known to affect serum lipid or glucose metabolism
• Active cardiovascular disease (for instance congestive heart failure) or recent (<6 months) event, such as acute myocardial infarction or cerebro-vascular accident
• not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in plant stanol or sterol esters 3 weeks before the start of the study
• men: consumption of >21 glasses of alcohol-containing drinks per week women: consumption of >14 glasses of alcohol-containing drinks per week
• abuse of drugs
• pregnant or breastfeeding women
• participation in another biomedical study within 1 month prior to the screening visit
• having donated blood (as blood donor) within 1 month prior to the screening visit or planning to do so during the study
• impossible or difficult to puncture as evidenced during the screening visits