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Completed

NCT Number: NCT04639765

Responses to Information on Treatments for Depression

The purpose of this study is to determine the impact of different messages about depression treatments.

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Key information

Conditions

Depressive Symptoms Behavior Behavioral Symptoms Depression

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Psychology Building 1835 Neil Avenue

Columbus, Ohio, 43210, United States

About this study

Participants recruited through Amazon Mechanical Turk (MTurk) will complete a screening questionnaire and provided the opportunity to consent to participate. Upon entry to the study, eligible participants will complete several questionnaires pre- and post-randomization. Randomization will be to view either a video detailing a type of depression treatment (cognitive behavioral therapy, antidepressant medication, or the combination of both treatments) with and without an emphasis on personalization. A no video condition is also included.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • PHQ-9 Score indicating a history of elevated depression symptoms
  • A high MTurk completion rate
  • Must pass all attention checks inserted into the questionnaires
  • No history of treatment for depression

Exclusion criteria

  • none

Treatment and study plan

CBT without Personalization

Other

Intervention involves a video describing CBT without a message about personalization.

CBT with Personalization

Other

Intervention involves a video describing CBT with a message about personalization.

ADM without Personalization

Other

Intervention involves a video describing antidepressant medication without a message about personalization.

ADM with Personalization

Other

Intervention involves a video describing antidepressant medication with a message about personalization.

Combined Treatment without Personalization

Other

Intervention involves a video describing the combination of cognitive behavior therapy and antidepressant medication without a message about personalization.

Combined Treatment with Personalization

Other

Intervention involves a video describing the combination of cognitive behavior therapy and antidepressant medication with a message about personalization.

Primary outcomes

  1. Regressed change from baseline in expectations on the Credibility/Expectancy Questionnaire (CEQ)

    Time frame: Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)

    The CEQ is a validated, commonly used measure assessing views of the credibility and expectations for benefit from a treatment.

  2. Regressed change from baseline in prognostic pessimism on an adapted version of the Perceptions of Depression Scale (PDS)

    Time frame: Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)

    Measured using an adapted version of the PDS, a validated scale measuring general prognostic pessimism. Minor changes to wording were made to directly address the three different interventions in the study (CBT, ADM, Combined Treatment).

Secondary outcomes

  1. Regressed change from baseline in affect on the Positive and Negative Affectivity Scale (PANAS)

    Time frame: Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)

    The PANAS is a widely used measure for positive and negative affect, and has been shown to be valid and reliable.

  2. Regressed Change from baseline on the Beck Hopelessness Scale (BHS)

    Time frame: Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)

    The BHS is the most widely used measure for hopelessness, and has been shown to be valid and reliable.

  3. Regressed change from baseline in personal and perceived depression stigma on the Depression Stigma Scale (DSS).

    Time frame: Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)

    The DSS is a valid and reliable measure for assessing personal and perceived stigma related to depression. The scale contains two subscales: personal stigma and perceived stigma.

  4. Regressed change from baseline in beliefs on the etiology of depression on the Reasons for Depression Questionnaire (RFD).

    Time frame: Up to 90 minutes to complete assessment. Assessed immediately pre- and post-intervention (on the same day)

    The RFD is a valid and reliable measure for assessing one's beliefs on the etiology of depression.

  5. Willingness to take a next step.

    Time frame: Up to 90 minutes to complete assessment. Assessed at the end of the study questionnaires (same day)

    Participants are given the option to learn more about finding cognitive behavioral therapy, antidepressant medications, or combination therapy. Based on their responses, they are provided links to relevant websites. This approach has been adopted from traditional marketing research to assess participants' responsiveness to a message.

Sponsors and collaborators

Lead sponsor

Ohio State University

Other

Registry information

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Nov 20, 2020
Registry last updated
Sep 5, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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