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Completed

NCT Number: NCT01122082

Respiratory Quotient and Food Liking, Food Wanting and Food Consumption

The purpose of this study is to observe the influence of carbohydrate-to-fat balance on liking, wanting and food consumption in humans.

16 normal-weight men (age: 23 ± 3 y)had completed a randomized 4-condition crossover study. The sessions differed by the composition of the breakfast which was rich in carbohydrates (HCB), low in carbohydrates (LCB), rich in fat (HFB) and low in fat (LFB). The HCB and HFB contained 2072 kJ, while the LCB and LFB contained 565 kJ. Two hours and 20 min later, energy expenditure (EE) and respiratory quotient (RQ) were measured before olfactory liking for 4 foods items and then ad libitum energy intake (EI) during a snack (sweet and fatty toast) were evaluated.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre des Sciences du Goût et de l'Alimentation

Dijon, 21000, France

About this study

In accordance with the carbohydrate-based models of feeding, one may expect that food choices as well as "liking" and "wanting" (the two components of the reward system) could be influenced by glycogen stores and the carbohydrate-to-fat balance. More precisely, one may expect that a high fat oxidation rate could increase liking and wanting carbohydrates to replenish glycogen stores and conversely, that a high carbohydrate oxidation rate could produce the reverse. In order to validate this hypothesis, the present study has been conducted to investigate in humans the influence of the carbohydrate-to-fat oxidation ratio on carbohydrate-to-fat selection and the food reward system.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Good health
  • Absence of medication
  • Moderate physical activity (irregular and less than 5 h/wk)
  • Low-smoking habit (less than 5 cigarettes/d)
  • Normal body mass index (20< BMI <25)

Exclusion criteria

  • Eating disorders
  • Dieting or fasting
  • Aversions for the foods offered and elevated 'cognitive restriction of eating' (score ≥ 7) according to the Three Factor Eating Questionnaire

Treatment and study plan

food preloads

Behavioral

Subjects will eat in the morning during breakfast 300g cottage cheese (627kJ - 147kcal; 13.2g carbohydrate, 0.3g fat, 23g protein) plus, according to the situations, either: 90g sucrose, HCB); 6g aspartame; 40g vegetable oil; 40g paraffin oil. Therefore two breakfast will have the same energy content (2072kJ - 495kcal), as did the other two(565 kJ - 135kcal).

Other names: food intake, metabolism

Primary outcomes

  1. Respiratory quotient

    Time frame: 6 months

    Respiratory quotient is the ratio of CO2 production on oxygen consumption measured in the expiratory flow

Secondary outcomes

  1. food liking

    Time frame: 6 months

    Food liking is the preference for 4 food items smelt

  2. food wanting

    Time frame: 6 months

    food wanting is the selection of 4 kind of toasts during a snack

  3. food consumption

    Time frame: 6 months

    is the amount of food eaten during the snack

Sponsors and collaborators

Lead sponsor

University of Burgundy

Other

Collaborators

  • Centre National de la Recherche Scientifique, France

Registry information

Official study title

Influence of Respiratory Quotient on Food Liking, Food Wanting, Macronutrient Selection and Food Consumption in Humans

Important dates

Study start
2008
Primary completion
2009
Study completion
2010
First posted
May 12, 2010
Registry last updated
Aug 24, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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