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Completed

NCT Number: NCT02243527

Respiratory Muscles and Inspiratory Muscle Training

The effects of inspiratory muscle training (IMT) remain controversial. Many studies have examined the effect IMT has on exercise performance, but any changes to the body that come from IMT have yet to be looked at.

This study will look at how someone breathes can change after IMT. Understanding how IMT changes the body can help us use IMT in different treatments.

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Key information

Conditions

Respiratory Muscles Behavior Breathing Exercises Motor Activity

Age range

19 year–39 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre for Heart Lung Innovation

Vancouver, British Columbia, V6Z 1Y6, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Recreationally active, 'Moderate' or 'High' category on International Physical Activity Questionnaire Short form questionnaire
  • Able to read and understand English
  • Pulmonary function within normal limits

Exclusion criteria

  • History of or currently smoking
  • History or current symptoms of cardiopulmonary disease (including asthma and exercise induced asthma)
  • Currently participating and training in a sport at a provincial, national, or international level
  • Ulcer or tumor in the esophagus, a nasal septum deviation, or recent nasopharyngeal surgery
  • Allergies to latex or local anesthetic
  • Contraindications to exercise testing

Treatment and study plan

Inspiratory Muscle Training

Other

6-weeks of inspiratory muscle training

Sham inspiratory muscle training

Other

A sham training procedure that is meant to elicit no physiologic changes

Primary outcomes

  1. Diaphragm Electromyography

    Time frame: Post Intervention - ie. immediately after 5 weeks of inspiratory muscle training

    Using a multipair esophageal electrode catheter we will determine any changes to the electric activity of the diaphragm.

    Diaphragm electromyography (EMG) has been expressed as %max. This unit is determined as the ratio of average EMG value (uV) divided by the maximal EMG activity (uV) generated during a maximal respiratory maneuver (inspiratory capacity during exercise).

Secondary outcomes

  1. Accessory Respiratory Muscle Activation

    Time frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training

    Using surface electromyography to determine the activation patterns of accessory respiratory muscles (scalene and sternocleidomastoid).

    Data are expressed as %max. This value is determined by taking the average electromyography (EMG) activity divided by the maximal EMG activity generated during a maximal inspiratory maneuver (inspiratory capacity during exercise).

Other outcomes

  1. Dyspnoea

    Time frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training

    Using the modified Borg scale to assess changes in perceived dyspnoea after inspiratory muscle training.

    The modified Borg scale is a 0-10 category ratio scale. The floor (0) of the scale is anchored subjectively to the subjects interpretation of "no breathing discomfort at all", and the ceiling (10) to represent "the most intense breathing discomfort they have experienced or could imagine experiencing".

  2. Muscle Oxygenation

    Time frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training

    Using near-infrared spectroscopy to examine if there are any relative changes in concentration (∆umol/Litre) of deoxygenated hemoglobin (HHb) after training. Deoxygenated hemoglobin is used as a surrogate of oxygen extraction specific to the local vasculature of the vastus lateralis,

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Collaborators

  • Natural Sciences and Engineering Research Council, Canada

Registry information

Official study title

Effects of Inspiratory Muscle Training on Respiratory Muscle Mechanics and Haemodynamics in Healthy Adults

Acronym: IMT

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Sep 18, 2014
Registry last updated
Jul 5, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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