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Completed

NCT Number: NCT03190031

Respiratory Muscle Training in CF Patients

The present study aims at evaluating the effect of respiratory muscle training in adult patients with cystic fibrosis on lung function, exercise performance and quality of life.

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Key information

Conditions

Cystic Fibrosis Behavior Congenital, Hereditary, and Neonatal Diseases and Abnormalities Digestive System Diseases Genetic Diseases, Inborn Infant, Newborn, Diseases Lung Diseases Motor Activity Pancreatic Diseases Respiratory Muscles Respiratory Tract Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital

Grenoble, 38000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a clinical diagnosis of cystic fibrosis
  • Patients in steady state

Exclusion criteria

  • Patients during exacerbation
  • Patients treated by oral corticotherapy (>0.5 mg/kg/j during >7 days) during the past 2 months
  • Pregnant patients

Treatment and study plan

Endurance respiratory muscle training

Other

Training program of the respiratory muscles in endurance by using sustained isocapnic hyperpnea

Resistance inspiratory muscle training

Other

Training program of the inspiratory muscles in resistance by using repeated inspiratory maneuvers against a resistance

Primary outcomes

  1. Respiratory muscle endurance

    Time frame: Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1)

    Total breathing duration (in min) measured during an incremental hyperpnea test

Secondary outcomes

  1. Respiratory muscle strength

    Time frame: Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1)

    Peak pressure (in mmHg) during maximal inspiratory and expiratory maneuvers

  2. Maximal cycling performance

    Time frame: Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1)

    Peak maximal power output (in W) during an incremental cycling test

  3. Quality of life of patients after the intervention

    Time frame: Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1)

    Score obtained during the questionnaire CQF14+

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Official study title

Respiratory Muscle Training in Patients With Cystic Fibrosis

Acronym: MUCOMUREE

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Jun 16, 2017
Registry last updated
Mar 23, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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