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NCT Number: NCT07027956

Respiratory Function and Oxygenation in Smokers and Non-smokers

This study aimed to compare respiratory function, exercise capacity, and intercostal muscle oxygenation in healthy smokers and non-smokers.

Recruiting

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Key information

Conditions

Smoking, Tobacco Behavior Smoking Tobacco Smoking Tobacco Use

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(Smokers):

  • According to the World Health Organization and ICD smoking addiction criteria, consuming at least one cigarette every day for the last year
  • Volunteering to participate in research
  • Able to walk and cooperate

Exclusion criteria

(Smokers):

  • Having any cardiopulmonary disease
  • Having a musculoskeletal problem that could affect the tests
  • Failure to comply with tests

Inclusion criteria

(Non-smokers):

  • According to the World Health Organization and ICD smoking addiction criteria, having never smoked or not having smoked in the last year
  • Volunteering to participate in research
  • Able to walk and cooperate

Exclusion criteria

(Non-smokers):

  • Having any cardiopulmonary disease
  • Having a musculoskeletal problem that could affect the tests
  • Failure to comply with tests

Treatment and study plan

Primary outcomes

  1. Forced vital capacity

    Time frame: 1st day

    Forced vital capacity (FVC) will be assessed using spirometry.

  2. Forced expiratory volume in one second

    Time frame: 1st day

    Forced expiratory volume in one second (FEV1) will be assessed using spirometry

  3. Forced expiratory volume in one second/forced vital capacity ratio

    Time frame: 1st day

    Forced expiratory volume in one second/forced vital capacity ratio will be assessed using spirometry.

  4. Peak expiratory flow

    Time frame: 1st day

    Peak expiratory flow (PEF) will be assessed using spirometry.

  5. Forced mid-expiratory flow

    Time frame: 1st day

    Forced mid-expiratory flow (FEF25-75) will be assessed using spirometry.

  6. Inspiratory muscle strength

    Time frame: 1st day

    Strength index will be evaluated.

  7. Exercise capacity

    Time frame: 2nd day

    will be evaluated with 6 minute walk test and total distance will be recorded.

  8. Intercostal muscle oxygenation

    Time frame: 2nd day

    During the 6-minute walking test, oxygenation of the intercostal muscles will be evaluated with a monitor.

Study contacts

Contact information is provided by the study sponsor or research team.

Merve Firat

CONTACT

[email protected]

+90 850 441 02 44 ext. 2490

Sponsors and collaborators

Lead sponsor

Kirsehir Ahi Evran Universitesi

Other

Registry information

Official study title

A Comparison of Respiratory Function, Exercise Capacity and Oxygenation Between Smokers and Non-smokers

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 19, 2025
Registry last updated
Jun 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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