Respiratory Complications of Operated Esophageal Atresia in Children

The respiratory complications of esophageal atresia have already been identified.

They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal reflux.

In this context, symptoms of asthma (or bronchial hyperreactivity) occur more frequently than in the general population and persist into adulthood. Their pathogenesis is still poorly understood and is the subject of much discussion.

The therapeutic management of these respiratory complications, poorly codified, remains very heterogeneous from one center to another. In France, the summary of knowledge is updated by the Reference Center for chronic and malformative diseases of the esophagus.

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Key information

Conditions

Esophageal Atresia Asthma Bronchial Diseases Bronchial Hyperreactivity Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Deglutition Disorders Digestive System Abnormalities Digestive System Diseases Esophageal Diseases Esophageal Motility Disorders Gastroesophageal Reflux Gastrointestinal Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

1 year–12 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre de Ressources et de Compétences de la Mucoviscidose (CRCM) - CHU de Strasbourg - France

Strasbourg, 67091, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Child aged 1 to 12 years old
Child operated on for esophageal atresia between 01/01/2010 and 31/12/2020 and followed up at the University Hospitals of Strasbourg
Child who has not expressed, after being informed, his opposition to the reuse of his data for the purposes of this research
Parental authority having not expressed, after being informed, their opposition to the reuse of their child's data for the purposes of this research.

Exclusion criteria

Subject and/or parental authority having expressed their opposition to participating in the study

Treatment and study plan

Primary outcomes

Retrospective study of respiratory complications of esophageal atresia in children

Time frame: Files analysed retrospectively from January 01, 2010 to December 31, 2020 will be examined

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Acronym: ATRESIA

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2022
First posted: Sep 6, 2022
Registry last updated: Nov 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed