Respiratory and Quadriceps Muscle Fatigability After an ICU Acquired Weakness

Muscle dysfunction can be lead to poor outcomes moreover ICU muscle weakness recovery are not correctly described.

The investigators aimed to assess the ability for quadriceps or respiratory muscles to repeat an effort at a maximal loading.

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Key information

Conditions

ICU Acquired Weakness

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Groupe Hospitalier du Havre

Montivilliers, Groupe Hospitalier Du Havre, 76290, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Mechanically ventilated at least at 24 Hours
Maximal inspiratory pressure < 30 centimeter of water
MRC score < 48/60

Exclusion criteria

Age < 18 years
Patients with neurological pathology or pre existing neuromuscular dysfunction
Patient unable to walk 50 meters before ICU admission
Patient with a thoracic or abdominal surgery
Inability to carry out maximal voluntary contraction

Treatment and study plan

muscle evaluation

Diagnostic Test

Repeated maximal voluntary contraction

Primary outcomes

Change in Respiratory muscle strength

Time frame: One day

Respiratory muscle strength will be assessed by Maximal Inspiratory pressure in centimeter of water. The measure will carry out by an electronical manometer
Change in quadriceps muscle strength

Time frame: One day

Quadriceps muscle strength will be assessed by Maximal Voluntary contraction of the quadriceps in Newton. The measure will carry out by an electronical dynamometer

Sponsors and collaborators

Lead sponsor

Groupe Hospitalier du Havre

Other

Registry information

Official study title

Comparison Between Respiratory and Quadriceps Muscle Fatigability During a Maximal Loading for ICU Weakness Patients

Important dates

Study start: 2022
Primary completion: 2023
Study completion: 2024
First posted: May 31, 2022
Registry last updated: Jul 11, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed