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Completed

NCT Number: NCT07536997

Resonance Breathing and Postural Resonance: Acute Modulation of Autonomic and Hemodynamic Responses Via Arterial Baroreflex Mechanisms

This study aimed to compare the acute autonomic and hemodynamic effects of two arterial baroreflex resonance interventions-Resonance Breathing (RB) and Postural Resonance (PR)-in healthy young adults. Methods: A randomized crossover design was conducted in 27 healthy participants (aged 18-25). Each participant completed three experimental sessions (control, RB, and PR) separated by a 5-day washout period. Each session included a 15-minute baseline, a 15-minute intervention, and a 5-min recovery phase. Continuous recordings of skin sympathetic nerve activity (SKNA) and heart rate variability (HRV) were collected throughout each session, while blood pressure (BP) and pulse wave velocity (PWV) were measured before and after the interventions.

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Key information

Conditions

Autonomic Nervous System Disease

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

No. 11, Gongyi Road, Dongcheng District, Beijing

Beijing, Dongcheng, 100010, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-30 years old

Exclusion criteria

  • No history of systematic professional sports training; Right-hand dominance (as assessed by the Edinburgh Handedness Inventory). Participants were excluded from the study if they had any of the following: Smoking, chronic alcohol consumption, or the use of psychotropic drugs or other substances affecting the nervous system; Irregular menstrual cycle; History of peripheral neuropathy or other autonomic nervous system disorders; Pre-existing cardiovascular diseases or abnormal electrocardiograms (ECG); Use of hormonal contraceptives; Uncontrolled hypertension or hypotension; Recent major life stressors; Regular practice of meditation or participation in psychotherapy; Presence of any movement disorders or inability to comprehend the experimental instructions.

Treatment and study plan

Resonance Breathing

Behavioral

A structured intervention focusing on resonance breathing ( slow, rhythmic breathing at spontaneous resonance frequency ) . The protocol aims to acutely modulate autonomic nervous system activity and hemodynamic responses via stimulation of the arterial baroreflex.

Postural Resonance

Behavioral

A structured intervention focusing on postural resonance alignment. The protocol aims to acutely modulate autonomic nervous system activity and hemodynamic responses via stimulation of the arterial baroreflex. Sessions include guided breathing practice, postural adjustment, and feedback on breathing mechanics

Primary outcomes

  1. Skin sympathetic nerve activity

    Time frame: Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)

    Skin sympathetic nerve activity (SKNA) was recorded non-invasively at the chest wall using a dedicated SKNA monitoring system. Measurements were obtained at baseline (pre-intervention) and immediately following completion of the resonance breathing and postural resonance intervention, to assess acute changes in sympathetic nervous system activity.

Secondary outcomes

  1. Changes in Resting Systolic and Diastolic Blood Pressure

    Time frame: Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)

    Resting systolic and diastolic blood pressure were measured in a seated position using a validated automated sphygmomanometer. Measurements were collected at baseline (pre-intervention) and immediately post-intervention, to evaluate acute hemodynamic changes following the resonance breathing and postural resonance intervention.

  2. Changes in Pulse Wave Velocity (PWV)

    Time frame: Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)

    Pulse wave velocity (PWV), a non-invasive marker of arterial stiffness, was assessed using a validated vascular screening device. Measurements were obtained at baseline (pre-intervention) and immediately post-intervention, to evaluate acute changes in arterial function following the intervention.

Sponsors and collaborators

Lead sponsor

Beijing Sport University

Other

Registry information

Acronym: Autonomic

Important dates

Study start
2024
Primary completion
2024
Study completion
2026
First posted
Apr 17, 2026
Registry last updated
Apr 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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