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Completed

NCT Number: NCT06095635

Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise in Coronary Paths

Introduction: Most cardiovascular diseases (CVD) can be prevented and controlled by adopting lifestyle changes, such as regular physical exercise and nutrition. Resveratrol and beverage extract promote beneficial health effects due to their nutritional properties. Objective: to analyze the effects of resveratrol supplementation and withdrawal extract on post-exercise recovery in coronary heart disease patients. Methods: men diagnosed with ischemic coronary artery disease will undergo four exercise protocols consisting of 30 minutes of aerobic exercise on an ergometric treadmill, with 5 minutes of warm-up, intensity of 30% of the heart rate reserve (HRR), followed by 25 minutes at intensity 60% of FCR and for a final 30 minutes of recovery in the supine position. Before each exercise protocol, all volunteers will consume: 500 mg of placebo (starch), or 500 mg of beetroot, or 500 mg of resveratrol and will also consume resveratrol and drink (500 mg each) 30 minutes before exercise. , the order of each supplementation will be done randomly. Cardiorespiratory parameters and heart rate variability (HRV) will be assessed at different times throughout the experimental procedure. To analyze the moments (rest versus recovery), the Bonferroni post-test will be used for parametric distribution or the Dunn post-test for non-parametric distribution. Statistical significance will be calculated at 5% for all analyses.

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Key information

Age range

40 year–79 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Universidade Estadual Paulista

Presidente Prudente, São Paulo, 19060-900, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult men over 45 years of age
  • diagnosed with ischemic coronary artery disease and with preserved left ventricular function (above 50%), confirmed by a previous echocardiogram

Exclusion criteria

Volunteers who present at least one of the following characteristics will be excluded:

  • smokers
  • alcohol drinkers
  • those who did not attend a cardiovascular rehabilitation program for at least 3 months prior to data collection
  • individuals who have known infections, metabolic and respiratory diseases that could interfere in cardiac autonomic control, unstable angina, uncontrolled hypertension, significant valvular disease, uncontrolled metabolic disease (e.g., uncontrolled diabetes and thyroid disease)

Treatment and study plan

Placebo Protocol

Other

ingestion of 500 mg of starch following 30 minutes of exercise (treadmill)

Other names: 500 mg of starch

Protocol Beet

Other

ingestion of 500 mg of beet extect following 30 minutes of exercise (treadmill)

Other names: 500 mg of beet extract

Protocol Resveratrol

Other

ingestion of 500 mg of resveratrol following 30 minutes of exercise (treadmill)

Other names: 500 mg of resveratrol

Protocol Beet and Resveratrol

Other

ingestion 500 mg of beet extect and 500 mg of resveratrol following 30 minutes of exercise (treadmill)

Other names: 500 mg of beet extect and 500 mg of resveratrol

Primary outcomes

  1. Heart rate variability (HRV)

    Time frame: through study completion, an average of 1 hour

    Time and frequency domain of HRV

Secondary outcomes

  1. Blood Pressure

    Time frame: through study completion, an average of 1 hour

    Systolic Blood Pressure and Diastolic Blood Pressure

Sponsors and collaborators

Lead sponsor

Universidade Estadual Paulista Júlio de Mesquita Filho

Other

Registry information

Official study title

Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise Submaximal Aerobic in Coronary Paths: a Study Prospective, Randomized Placebo-controlled

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Oct 23, 2023
Registry last updated
Oct 23, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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