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Completed

NCT Number: NCT04496570

Resolvin D1 Levels in Patients With Periodontitis

The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.

A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

30 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ordu University

Ordu, 52200, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Stage 3, Grade B and generalized periodontitis patients

Exclusion criteria

  • excessive forces;
  • presence of systemic diseases
  • administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
  • having received non-surgical periodontal treatment within the past 6 months
  • allergy or sensitivity to any drug,
  • pregnancy, lactation
  • current and former use of tobacco.

Treatment and study plan

periodontal therapy

Procedure

Non surgical periodontal therapy was performed to patients with peridontitis

Primary outcomes

  1. Biochemical parameter (resolvin D1)

    Time frame: Baseline and 1 month after NSPT

    The changes in levels of resolvin D1 after periodontal treatment determined by ELISA.

Secondary outcomes

  1. Probing pocket depth

    Time frame: Baseline and 1 month after NSPT

    The changes in probing pocket depth after periodontal treatment were evaluated

  2. Clinical attachment level (CAL)

    Time frame: Baseline and 1 month after NSPT

    The changes in CAL after periodontal treatment were evaluated

  3. Plaque index (PI)

    Time frame: Baseline and 1 month after NSPT

    The changes in PI after periodontal treatment were evaluated

  4. Gingival index (GI)

    Time frame: Baseline and 1 month after NSPT

    The changes in GI after periodontal treatment were evaluated

Sponsors and collaborators

Lead sponsor

Ordu University

Other

Registry information

Official study title

The Role of Resolvin D1 in Maintaining Oral Health

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Aug 3, 2020
Registry last updated
Aug 19, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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