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Completed

NCT Number: NCT06078358

Resistance Exercise Training in Children.

The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength, activation, and lipids of the vastus lateralis.

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Key information

Conditions

Resistance Training Behavior Motor Activity

Age range

8 year–10 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hoglund Biomedical Imaging Center, Kansas City, Kansas, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteer males and females ages 8 - 10 years.

Exclusion criteria

  • No history or ongoing neuromuscular diseases, musculoskeletal injuries, or a disease that effects metabolism.

Treatment and study plan

Resistance Exercise Training

Other

Traditional linear periodization resistance training.

Primary outcomes

  1. Change in the muscular strength of leg extensors, as measured with isometric strength.

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect the strength of the leg extensors. The higher score, reflects greater muscular strength.

Secondary outcomes

  1. Change from baseline in motor unit firing rates during a 60% of maximal voluntary contraction (MVC).

    Time frame: baseline, following the intervention (9 weeks)

    Scores are measured with the y-intercept from the firing rates versus recruitment threshold relationships from the 60%. The higher y-intercept score reflects greater muscle activation.

  2. Change from baseline in motor unit firing rates during a 60% of maximal voluntary contraction (MVC).

    Time frame: baseline, following the intervention (9 weeks)

    Scores are measured with the slope from the firing rates versus recruitment threshold relationships from the 60%. The higher slope score reflects greater muscle activation.

  3. Change from baseline in thigh muscle cross-sectional area.

    Time frame: baseline, following the intervention (9 weeks)

    Scores are measured cross-sectional area from ultrasound images.

Other outcomes

  1. Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect a saturation level of fatty acids in the extramyocellular lipid. The higher score, reflects greater fatty acid saturation.

  2. Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect a saturation level of fatty acids in the intramyocellular lipid. The higher score, reflects greater fatty acid saturation.

  3. Change from baseline in motor unit firing rates during a 35% of maximal voluntary contraction (MVC).

    Time frame: baseline, following the intervention (9 weeks)

    Scores are measured with the y-intercepts from the firing rates versus recruitment threshold relationships from the 35%. The higher y-intercept score reflects greater muscle activation.

  4. Change from baseline in motor unit firing rates during a 35% of maximal voluntary contraction (MVC).

    Time frame: baseline, following the intervention (9 weeks)

    Scores are measured with the slopes from the firing rates versus recruitment threshold relationships from the 35%. The higher slope score reflects greater muscle activation.

  5. Change from baseline in intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect a concentration. The higher score, reflects more fat in the fibers.

  6. Change from baseline in extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    Time frame: baseline, following the intervention (9 weeks)

    The score will reflect a concentration. The higher score, reflects more fat in the fibers.

Sponsors and collaborators

Lead sponsor

University of Kansas Medical Center

Other

Collaborators

  • National Strength and Conditioning Association

Registry information

Official study title

The Effects of Resistance Exercise on Muscle Activation and Lipids in Children

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Oct 11, 2023
Registry last updated
Oct 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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