Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity

Inclusion criteria

• Both biological parents are of Han ethnicity;
• Age range: 18 to 45 years old, gender not restricted;
• Meets the clinical diagnostic criteria for bipolar disorder as stipulated in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5);
• Body Mass Index (BMI) ≥ 28 kg/m2, or for males, waist circumference ≥ 90 cm and for females, waist circumference ≥ 85 cm;
• HAMD-24 score < 7 points, YMRS score < 5 points;
• All included researchers and their family members have given informed consent for this study.

Exclusion criteria

221/5000

• Individuals with other DSM-5 spectrum disorders;
• Mental disorders caused by substance abuse (such as alcohol, drugs, etc.), and those with severe physical illnesses;
• Those who consumed food or microecological preparations containing probiotics, prebiotics, etc. within one week before enrollment, and had a history of respiratory, urinary, digestive system infections and antibiotic use within one month before enrollment;
• Those currently having serious suicidal thoughts or behaviors, or those with severe agitation;
• Those who cannot follow medical advice for treatment, or those without guardians;
• Pregnant or lactating women, or those planning to become pregnant;
• Those who cannot complete MRI examinations due to special conditions such as having metal implants or pacemakers in their bodies.