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NCT Number: NCT06502405

Research on the Application of Electrical Impedance Tomography in Bronchial Challenge Testing

The purpose of this study was to examine whether electrical impedance tomography (EIT) was capable of identifying the deteriorated lung function on a regional level during bronchial challenge testing and whether EIT may provide additional information during bronchial challenge testing and identify spatial and temporal heterogeneity of regional lung function.

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

About this study

The content of this study includes:

  • Can EIT identify the uneven ventilation caused by airway contraction in patients during bronchial provocation tests.
  • Can EIT monitor airway contraction in patients before Spirometer examination after inhaling activators.
  • Can EIT observe uneven ventilation caused by airway contraction through tidal breathing after the patient inhales activator.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

：

  • Patients suspected of asthma who require bronchial challenge testing.
  • The Bronchodilator responsiveness testing is negative.
  • patients with a pre-bronchodilator FEV1 >60% predicted.
  • No contraindications for bronchial provocation test examination.
  • Fully understand the purpose and significance of this study, and voluntarily participate in the research.

Exclusion criteria

  • patients with a pre-bronchodilator FEV1≤60% predicted.
  • Contraindications for bronchial challenge testing.
  • Pregnant or lactating women.
  • After pacemaker surgery.

Treatment and study plan

Primary outcomes

  1. global inhomogeneity index （GI）

    Time frame: 1day

    Measured by EIT, used to describe the overall degree of spatial heterogeneity of ventilation.

  2. forced expiratory volume in 1s (FEV1)

    Time frame: 1day

    The forced expiratory volume in 1s measured during pulmonary function tests.

Study contacts

Contact information is provided by the study sponsor or research team.

Lu Cao, Master

CONTACT

[email protected]

13810389517

Sponsors and collaborators

Lead sponsor

wang kaifei

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Jul 16, 2024
Registry last updated
Jul 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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