Release of Proinflammatory Cytokines (IL-1β, IL-6) and Total-prostaglandin (PG) Following Femtosecond Laser-assisted Cataract Surgery Compared to Manual Cataract Surgery

Patients with bilateral age related cataract will be included in the study. Manual cataract surgery (MCS) will be performed in one eye and laser cataract surgery (LCS) in the corresponding eye. LCS will be performed with an approved femtosecond laser (FSL) device with an integrated imaging system.

After surgery aqueous humour will be collected and screened with Enzyme-linked Immunosorbent Assay (ELISA) Kits for Interleukin-1β; Interleukin-6 and PG.

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Key information

Conditions

Age Related Cataracts

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical University of Vienna

Vienna, 1090, Austria

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Bilateral age-related cataract necessitating phacoemulsification extraction and posterior intraocular lens implantation.
Pupil dilation of ≥ 6.5mm
Age 40 and older

Exclusion criteria

Corneal abnormality
Pseudoexfoliation
Preceding ocular surgery or trauma
Uncontrolled glaucoma
Proliferative diabetic retinopathy
Iris neovascularization
History of uveitis/iritis
Microphthalmus
Recurrent intraocular inflammation of unknown etiology
Blind fellow eye
Uncontrolled systemic or ocular disease
Pregnancy
Lactation

Treatment and study plan

Femtosecond Laser-assisted

Device

Laser cataract surgery will be performed in one eye

Manual Cataract Surgery

Procedure

Manual cataract surgery will be performed in contralateral eye

Primary outcomes

Proinflammatory cytokines (IL-1β, IL-6) and total-PG

Time frame: 5 minutes after laser procedure

Interleukin IL-1β, Interleukin IL-6, total-prostaglandin

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Registry information

Official study title

Intraindividual Comparison of Proinflammatory Cytokines (IL-1β, IL-6) and Total-prostaglandin (PG) Following Femtosecond Laser-assisted Cataract Surgery Using a Low-energy, High-frequency Femtosecond Laser-Device Compared to Manual Cataract Surgery

Important dates

Study start: 2016
Primary completion: 2016
Study completion: 2016
First posted: Jan 4, 2018
Registry last updated: Jan 5, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed