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NCT Number: NCT05373836

Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery

There are several predictors of clinical outcome in patients undergoing brain tumor surgery. Among those, nutritional parameters and calculated nutritional index are known to have ability to predict mortality and clinical outcomes in some patients with brain tumor. However, there are lack of consistent results on predictability of nutritional index and clinical outcome in patients undergoing brain tumor surgery.

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Key information

Conditions

Clinical Outcome

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, 03080, South Korea

About this study

In this retrospective study, we evaluated the relationship between prognostic nutritional index, which was calculated from laboratory parameters, and clinical outcome including mortality in patients undergoing brain tumor surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea

Exclusion criteria

  • Lack of results of laboratory parameters, such as serum albumin, lymphocyte count, cholesterol
  • Lack of data on clinical outcome, including mortality, acute kidney injury, renal replacement therapy, length of hospital stay, and other major adverse outcome

Treatment and study plan

prognostic nutritional index calculated from laboratory parameters

Diagnostic Test

Calculated nutritional index using laboratory results of serum albumin, lymphocyte count, and cholesterol

Primary outcomes

  1. predictability of prognostic nutritional index for mortality after brain tumor surgery

    Time frame: From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years

    Odds ratio of prognostic nutritional index for postoperative mortality

Secondary outcomes

  1. predictability of prognostic nutritional index for acute kidney injury after brain tumor surgery

    Time frame: From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years

    Odds ratio of prognostic nutritional index for postoperative acute kidney injury

  2. predictability of prognostic nutritional index for renal replacement therapy after brain tumor surgery

    Time frame: From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years

    Odds ratio of prognostic nutritional index for postoperative renal replacement therapy

  3. relationship of prognostic nutritional index for length of hospital stay after brain tumor surgery

    Time frame: From date of surgery until the date of hospital discharge

    Odds ratio of prognostic nutritional index for length of hospital stay

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
May 13, 2022
Registry last updated
Feb 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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