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Completed

NCT Number: NCT05680350

Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility

The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.

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Key information

Conditions

Infertility Unexplained Endometriosis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Urogenital Diseases

Age range

30 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Banha University

Banhā, El- Qalyobia, 13511, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 30-45 years old
  • Unexplained infertility

Exclusion criteria

  • Presence of other causes of infertility,
  • age out of the predetermined range,
  • the presence of immune disorders,
  • maintenance on immunosuppressive drugs

Treatment and study plan

Laparoscopic Exploration

Procedure

Laparoscopic Exploration to diagnose & grade endometriosis

Estimation of Plasma Expression level of MICRO RNA 203 & 210

Diagnostic Test

estimation of Plasma Expression level for Gene"Micro RNA "203 & 210" by qRT-PCR

Primary outcomes

  1. grading of endometriosis

    Time frame: 8 months

    The diagnostic performance of estimated plasma levels of microRNA for diagnosis and grading endometriosis

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Plasma Levels of Micro RNA 203 and 210 Might Spare the Exploratory Laparoscopy in Case of un Explained Infertility With Suspected Endometriosis

Important dates

Study start
2020
Primary completion
2021
Study completion
2022
First posted
Jan 11, 2023
Registry last updated
Jan 11, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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