Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm

Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm.

The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.

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Key information

Conditions

Abdominal Aortic Aneurysm Aneurysm Aortic Aneurysm Aortic Aneurysm, Abdominal Aortic Diseases Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Aarhus university hospital skejby department of cardio thoracic and vascular surgery

Aarhus, Region Midt, 8200, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with ruptured abdominal aortic aneurysm offered surgery
Age > 18 years

Exclusion criteria

Technical inoperable

Treatment and study plan

Precondition

Procedure

Precondition on a arm in four intervals at start of surgery for ruptured aortic aneurysm

Primary outcomes

Reduction in myocardial infarction

Time frame: 4 to 5 years

Secondary outcomes

Improvement in survival Description on inflammatory response

Time frame: 4 to 5 years

Sponsors and collaborators

Lead sponsor

Nikolaj Eldrup

Other

Collaborators

Aarhus University Hospital
Aarhus University Hospital Skejby

Registry information

Acronym: PreconRAAA

Important dates

Study start: 2009
Primary completion: 2014
Study completion: 2014
First posted: Apr 17, 2009
Registry last updated: Jan 14, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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