Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study

Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases. This study will examine differences between ethnic groups (White, Black, South Asian and Mixed/Other) and first lifetime presentation of twelve different cardiovascular diseases. This information may help to predict the onset of cardiovascular diseases and inform disease prevention strategies.

The hypothesis is that different ethnic groups have differing associations with the range of cardiovascular diseases studied.

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Key information

Conditions

Abdominal Aortic Aneurysm Aneurysm Angina Pectoris Angina, Stable Angina, Unstable Aortic Aneurysm Aortic Aneurysm, Abdominal Aortic Diseases Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Brain Diseases Brain Ischemia Cardiac Arrest Cardiovascular Diseases Central Nervous System Diseases Cerebral Hemorrhage Cerebrovascular Disorders Chest Pain Coronary Disease Coronary Heart Disease Death Death, Sudden Death, Sudden, Cardiac Heart Arrest Heart Diseases Heart Failure Hemorrhage Infarction Intracerebral Haemorrhage Intracranial Hemorrhages Ischemia Ischemic Attack, Transient Ischemic Stroke Myocardial Infarction Myocardial Ischemia Necrosis Nervous System Diseases Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Peripheral Arterial Disease Peripheral Vascular Diseases Signs and Symptoms Stable Angina Pectoris Stroke Subarachnoid Haemorrhage Subarachnoid Hemorrhage Sudden Cardiac Death Transient Ischemic Attack Unstable Angina Vascular Diseases

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

There is evidence from epidemiological studies that different ethnic groups are associated with increased incidence of specific cardiovascular diseases. However, the majority of existing studies have examined associations with one or two acute conditions such as stroke or coronary heart disease or focused on a particular ethnic group.

The aim of this study is to examine the differing associations between four ethnic groups and the initial lifetime presentation of a broad range of cardiovascular diseases, including chronic presentations such as stable angina. The hypothesis is that there will be heterogeneity of associations between the different ethnic groups and the full range of cardiovascular diseases studied.

The study will use data from the CALIBER data set of clinically collected electronic health record data from England.

This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the National Institute for Health Research (NIHR) and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (Clinical Practice Research Datalink - CPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER data set).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 30 and over
Registered with a participating general practice during the study period
Minimum one year of records prior to study entry meeting CPRD data quality

Exclusion criteria

Patients without a record of ethnic group
Patients without record of gender
Patients with prior atherosclerotic disease, as recorded in primary care or hospitalisation data
Pregnant women in the 6 months before the eligibility date

Treatment and study plan

Primary outcomes

Initial presentation of cardiovascular disease

Time frame: 10 years

First recorded diagnosis of cardiovascular disease during follow-up: ventricular arrhythmia / sudden cardiac death, heart failure, unheralded coronary death, myocardial infarction, unstable angina, stable angina, abdominal aortic aneurysm, peripheral arterial disease, subarachnoid haemorrhage, intracerebral haemorrhage, ischaemic stroke, transient ischaemic attack

Secondary outcomes

All cause mortality

Time frame: 10 years

Sponsors and collaborators

Lead sponsor

University College, London

Other

Collaborators

London School of Hygiene and Tropical Medicine
National Institute for Health Research, United Kingdom
Wellcome Trust

Registry information

Official study title

Ethnicity and Incidence of Twelve Cardiovascular Diseases: A CALIBER Study

Important dates

Study start: 2013
Primary completion: 2016
Study completion: 2017
First posted: Jun 26, 2014
Registry last updated: Jun 8, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed