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NCT Number: NCT05874479

Reducing AIR Pollution Exposure to Lower Blood PRESSURE Among New York City Public Housing Residents

Fine particulate matter <2.5 µm (PM2.5) air pollution is the fifth leading risk factor for global mortality, with the largest portion of deaths due to cardiovascular disease (CVD). While several mechanisms are responsible, PM2.5-induced elevations in blood pressure (BP) may be relevant. Indoor portable air cleaners (PACs) are a novel approach to reduce exposure to PM2.5 and potentially lower blood pressure. The current study is being conducted to provide evidence that PACs reduce PM2.5 exposure and lower systolic blood pressure (SBP) in key patient populations.

Recruiting

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Key information

Conditions

Blood Pressure

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

NYU Langone Health

New York, 10016, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • self-reported nonsmokers living in a nonsmoking household.
  • adults living with hypertension (HTN) from NYC public housing.

Exclusion criteria

  • History of major known arrhythmias (e.g. atrial flutter or fibrillation, ventricular tachycardia).
  • Screening systolic BP ≥160 mm Hg or diastolic BP ≥100 mm Hg (i.e. severe hypertension by the 2017 ACC/AHA BP guideline).
  • A change in drug regimen in the prior 2 weeks or a planned change in drug regimen during the first 30 days for those taking antihypertensive medication.
  • Current smoking or living with an active smoker who smokes indoors
  • Planned travel out of NYC for ≥2 weeks in next 6 months
  • Incarcerated
  • Pregnant
  • Unable/unwilling to consent
  • Established cardiovascular disease
  • End-stage renal disease (chronic kidney disease stage IV or on dialysis)
  • Barrier to technology use (e.g., visual or hearing impairment)
  • Lung disease requiring oxygen
  • Cancer receiving treatment

Treatment and study plan

Active PAC

Device

The active PAC will contain HEPA filters inside the device.

Sham PAC

Device

The sham PAC will contain no HEPA filters inside the device.

Primary outcomes

  1. Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 30 Days

    Time frame: Up to Day 30

    Participants measure HBP every day between 6-9 am.

Secondary outcomes

  1. Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 90 Days

    Time frame: Up to Day 90

    Participants measure HBP every day between 6-9 am.

  2. Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 180 Days

    Time frame: Up to Day 180

    Participants measure HBP every day between 6-9 am.

Study contacts

Contact information is provided by the study sponsor or research team.

Elle Anastasiou Pesante

CONTACT

[email protected]

(646) 501-3613

Jonathan Newman

CONTACT

[email protected]

(212) 263-9393

Sponsors and collaborators

Lead sponsor

NYU Langone Health

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Acronym: AirPressureNYC

Important dates

Study start
2023
Primary completion
2027
Study completion
2028
First posted
May 25, 2023
Registry last updated
Oct 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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