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NCT Number: NCT07425353

Rebound Therapy on Ventilatory Functions in Down Syndrome

The purpose of this study is to examine the effects of rebound therapy on ventilatory functions in children with Down Syndrome.

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Key information

About this study

Down syndrome (DS) is one of the common congenital anomalies associated with a high rate of various medical disorders including congenital cardiac defects, visual and auditory affection, musculoskeletal system, and autoimmune disorders. Respiratory involvement is common in DS and is a leading cause of death. Rebound therapy from quality of mini trampoline provides all benefits of other aerobic exercise without the stress impact usually associated with vigrous activity. Several studies support the use of rebound therapy among different areas while, there is no research conducted on ventilatory functions in children with Down Syndrome. Hence, there is need to study the effect of rebount therapy on ventilatory functions in children with Down Syndrome.

Fourty children with Down syndrome (based on power analysis) from both sexes (9-13 years) will be recruited from different schools of special education. They will be divided randomly into control group (20 children) and study group (20 children). The control group will receive a chest physical therapy protocol that included respiratory exercises and incentive spirometer training. The study group will receive a rebound therapy using mini trampoline.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children ages will be ranged from 9 to 13 years old.
  • Mild and moderate mental retardation with IQ level between 50-70 based on Stanford-Binet intelligence scale.
  • Functional hearing and vision.
  • Independent standing and walking.

Exclusion criteria

  • Symptomatic pain.
  • Musculoskeletal problems or/ atlanto-axial instability.
  • Rheumatic and congenital heart disease
  • History of previous surgical operation
  • Regular participation in any sport activities.

Treatment and study plan

Chest Physical Therapy Protocol

Other

The chest physical therapy protocol include respiratory exercises and incentive spirometer training.

Rebound Therapy Protocol

Other

The chest physical therapy protocol include respiratory exercises and incentive spirometer training + rebound therapy protocol using mini-trampoline training

Primary outcomes

  1. Forced Vital Capacity (FVC)

    Time frame: Up to 12 weeks

    Spirometry will be used to measure forced vital capacity (FVC). It is the maximum volume of gas that can be expired when the child exhales as forcefully and as rapidly as possible after a maximal inspiration to assess the overall ability to move air in and out of the lungs. It is expressed in liter/minute.

  2. Forced Expiratory Volume in the First Second (FEV1)

    Time frame: Up to 12 weeks

    Spirometry will be used to measure forced expiratory volume in the first second (FEV1). It is the volume of gas expired over a given time interval (the first second) from the beginning of the FVC maneuver that reflects airflow in the large airways. It is expressed in liter/minute.

Secondary outcomes

  1. Chest Expansion

    Time frame: Up to 12 weeks

    Tape measures will be used to measure chest expansion.

  2. Functional Mobility

    Time frame: Up to 12 weeks

    Six-minute walk test will be used for measuring functional mobility. It is a sub-maximal test of aerobic capacity, in which the subjects walk as far as possible in 6 minutes (min.) around a premeasured distance

Study contacts

Contact information is provided by the study sponsor or research team.

Eman Wagdy, PH.D

CONTACT

[email protected]

01008079576

Sponsors and collaborators

Lead sponsor

Beni-Suef University

Other

Registry information

Official study title

Effect of Rebound Therapy on Ventilatory Functions in Children With Down Syndrome. A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 20, 2026
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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