Real-world Comparative Effectiveness of Rivaroxaban Versus VKA

Inclusion criteria

• NVAF(non-valvular atrial fibrillation) will be defined as the occurrence of 2 or more inpatient or outpatient claims with ICD(International Classification of Disease)-9 427.31 as the diagnosis code at any time in the patient's data history prior to inclusion
• Patients will be required to have 180 days of enrollment for the assessment of baseline characteristics
• CHA2DS2-Vasc score ≥2 during the 180 days prior to index rivaroxaban use baseline period (CHA2DS2-Vasc: Diabetes mellitus; S2: prior Stroke or TIA or Thromboembolism; V: Vascular disease; A: Age 65-74 years; Sc: Sex category)

Exclusion criteria

• Patients <18 years of age
• Patients with valvular AF (Atrial fibrillation)
• Pregnancy
• Malignant cancers
• Transient cause of AF
• Patients with venous thromboembolism (pulmonary embolism or deep vein thrombosis)
• Patients with major surgery defined as hip or knee replacement
• Prescriptions of oral anticoagulants (OACs) (apixaban, warfarin, dabigatran, rivaroxaban) before index date
• Prescription of more than one OAC on the index date
• Patient with any of the events defined in the composite endpoint

• Fatal bleeding
• Fatal Stroke/Myocardial infarction
• Intracranial hemorrhage
• Ischemic stroke
• Myocardial infarction