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OpenTrials
Completed

NCT Number: NCT07424768

Re-operative Hypospadias Repair Using Tubularized Incised Plate Urethroplasty

The aim of this study is to evaluate the outcomes, feasibility, and complication profile of re-operative hypospadias repair using tubularized incised plate urethroplasty as a single-stage procedure in a single-center experience.

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Key information

About this study

Hypospadias repair remains one of the most common reconstructive procedures in pediatric urology; however, re-operative hypospadias represents a challenging subset due to distorted anatomy, urethral plate scarring, deficient local tissues, and higher complication rates compared with primary repairs.

The tubularized incised plate (TIP) urethroplasty, originally described by Snodgrass, revolutionized primary hypospadias repair and has since been adapted for selected reoperative cases. Contemporary evidence suggests that despite prior surgery and scary, a well-vascularized urethral plate of adequate width can still be successfully tubularized following a midline relaxing incision, offering acceptable functional and cosmetic outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both sexes.
  • Children with recurrent or residual hypospadias in whom the urethral plate is deemed suitable for reuse, defined as a plate width of at least 8-9 mm with acceptable vascularity and without severe fibrosis.

Exclusion criteria

  • Patients with severely scared or fibrotic urethral plates are not suitable for tubularization.
  • Absent or destroyed urethral plates following previous failed hypospadias repairs.
  • Patients require staged urethral reconstruction rather than a single-stage procedure.
  • Presence of poor urethral plate vascularity or ischemic tissue.
  • Extensive penile scarring or fibrosis resulting from multiple previous surgical attempts.
  • Severe penile curvature requiring excision of the urethral plate.
  • Inability to achieve adequate, well-vascularized tissue coverage over the neourethra.

Treatment and study plan

Tubularized Incised Plate Urethroplasty

Procedure

All procedures were performed under general anesthesia using the tubularized incised plate technique. After completing penile degloving and exposure of the urethral plate, a midline longitudinal incision was made along the entire length of the plate to allow tension-free tubularization. The urethral plate was then tubularized over an appropriate-sized urethral catheter using fine absorbable sutures. A well-vascularized dartos flap was harvested and interposed as a protective layer over the neourethra, followed by meticulous skin closure.

Primary outcomes

  1. Success rate

    Time frame: 6 months after the procedure

    The success rate of tubularized incised plate urethroplasty reoperation after treatment was recorded.

Secondary outcomes

  1. Incidence of complications

    Time frame: 6 months after the procedure

    Incidence of postoperative complications such as fistula, meatal stenosis, glans dehiscence, and urethral stricture were recorded.

  2. Incidence of postoperative urethrocutaneous fistula

    Time frame: 6 months after the procedure

    Incidence of postoperative urethrocutaneous fistula was recorded.

  3. Incidence of meatal stenosis

    Time frame: 6 months after the procedure

    Incidence of meatal stenosis was recorded.

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Feb 20, 2026
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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