Rapid Acclimatization to Hypoxia at Altitude

Inclusion criteria

• normotensive (i.e. <140/90 mmHg)

Exclusion criteria

• Pregnancy
• nursing mother
• current tobacco use or regular use within the previous two years
• use of prescription medication other than birth control
• asthma or any other type of lung/respiratory dysfunction
• resting oxygen saturation <95%
• unwillingness to abstain from exercise for 48 hours prior to laboratory testing
• use of anticoagulant therapy or have a known or suspected bleeding disorder
• identification of contraindication during screening (i.e. positive stress test)
• any history of mountain sickness (altitude sickness)
• any history of allergic reaction, hypersensitivity or idiosyncratic reaction to any of the products administered during the study, including allergy to any sulfa or sulfonamide derivatives
• history of clinically significant illness within 4 weeks prior to Day 1
• Subjects who have made any significant donation (including plasma) or have had a significant loss of blood within 30 days prior to visit 1
• receipt of a transfusion or any blood products within 30 days prior to visit 1.