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OpenTrials
Completed

NCT Number: NCT06552702

Race and Socioeconomic Position: Examining Common Social Pathways to Disease Risk

Black Americans and those of lower socioeconomic position (SEP) are at higher risk for multiple diseases of aging and shorter lifespans, but the psychophysiological mechanisms that may account for these effects are not clear. The overarching objective of this pilot grant is to improve our understanding of the proximal social exposures and subsequent psychobiological processes that contribute to racial and socioeconomic health disparities. Precisely understanding what these mutable social and psychological mechanisms are is necessary in order to identify intervention targets at the level of the individual.

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Key information

Conditions

Age range

35 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of AL Psychology Department

Tuscaloosa, Alabama, 35404, United States

About this study

Black Americans and those of lower socioeconomic position (SEP) are at higher risk for multiple diseases of aging and shorter lifespans. Though these disparities are well-documented, the mechanisms that may account for them are still poorly understood. Low income or Black race do not, themselves, cause individuals to become sick. Instead, the social context and exposures associated with these personal attributes give rise to differential risk (1-3). Black race and lower SEP are overlapping in the United States and race and SEP may share common social exposures that contribute to disease risk because both Blacks and individuals of lower SEP are socially marginalized (e.g., devalued, pushed to the lower margins of society) and thus exposed to more stress associated with lower hierarchical rank (4). However, no studies to our knowledge have been designed to examine whether day-to-day social exposures common across race and SEP may contribute to higher overall disease burden in these groups. In this project, investigators examine whether daily social interaction patterns help to explain how race and SEP may be linked with well-established psychobiological pathways to disease (affect, behavior, and physiology). With respect to each of these pathways, investigators examine the extent to which within-person changes in social processes may be associated with effects that mirror (and thus could explain) between-group differences. For example, interactions in which one experiences a higher degree of disrespect may be associated with momentary changes in affect, behavior, and physiology that confer disease risk. Examination of these within-person processes allows for stronger causal inference and is directly relevant to the development of individual-level interventions (e.g., targeting cognitive, behavioral, and affective processes). These findings can directly inform individual and group interventions for stress reduction in health disparity populations.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Black American or White American between the ages of 35 and 70.

Exclusion criteria

  • Conditions that require immediate treatment (e.g., Stage 2 hypertension; resting blood pressure > 160/100 mmHg)
  • Excessive alcohol consumption (> 5 portions, > 3 times per week)
  • Frequent illicit drug use
  • Schizophrenia or bipolar disorder
  • Permanent neurological deficit
  • Shift work
  • Current pregnancy

Treatment and study plan

There is no intervention

Other

There is no intervention.

Primary outcomes

  1. Ambulatory Systolic Blood Pressure

    Time frame: during four days of ambulatory monitoring

    Mean

  2. Ambulatory Diastolic Blood Pressure

    Time frame: during four days of ambulatory monitoring

    Mean

Sponsors and collaborators

Lead sponsor

University of Alabama, Tuscaloosa

Other

Collaborators

  • University of Alabama at Birmingham

Registry information

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Aug 14, 2024
Registry last updated
Aug 14, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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