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Completed

NCT Number: NCT06614556

Quantifying the Trainability of Peripheral Nerve Function in Young and Older Adults.

The purpose of this project is to identify the effects of hand grip resistance training on nerve speed of the hand muscles and to quantify whether age plays a role in those effects. Two groups (young and older adults) underwent a 4-week resistance training intervention with nerve conduction velocity measured before and after. There were also two control groups (young and older adults) who performed the testing 4 weeks apart, but did not engage in the intervention.

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Key information

Conditions

Nerve Degeneration Healthy Aging Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Applied Neuromuscular Physiology Laboratory

Stillwater, Oklahoma, 74078, United States

About this study

Studies have shown that nerve speed slows with advancing age. As a result, slower nerves may result in slower movement speed and can alter response time. The investigators propose that a resistance training intervention may elicit positive adaptations to the nerves. The purpose of this project is to identify the effects of hand grip resistance training on nerve speed of the hand muscles and to quantify whether age plays a role in those effects. Two groups (young and older adults) underwent a 4-week, at-home, resistance training intervention with nerve conduction velocity (m/s) measured before and after. There were also two control groups (young and older adults) who performed the testing 4 weeks apart, but did not engage in the intervention. Other outcome measures included nerve size, via ultrasound, maximal handgrip strength, and hand dexterity.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Apparently healthy adults 18 - 100 years old.

Exclusion criteria

  • If you have been notified by a physician to refrain from exercise due to cardiovascular issues.
  • Known orthopedic or neuromuscular limitations or illness of the upper extremities.
  • Known neuromuscular disorders.
  • Individuals that are experiencing a fever (> 100.4° F) or have identified as symptomatic on the COVID-19 screening questionnaire may not participate at this time.

Treatment and study plan

Resistance training

Other

Participants in the training groups performed bilateral hand grip resistance training three times per week for four weeks using a specialized hand-grip kit provided to them. Participants were provided with pictures and instructions for each exercise upon completion of the initial testing (PRE) session. They were asked to perform 12 training sessions (approximately 30-45 mins) over the 4 weeks according to their schedule. Each participant was asked to keep a training log to assist with accountability. Those assigned to the control groups were asked to maintain their normal daily activities throughout the four weeks.

Other names: Strength Training, Exercise

Primary outcomes

  1. Motor nerve conduction velocity (m/s)

    Time frame: Before and after 4 weeks of training (or just 4 weeks, for controls)

    Conduction velocity of the median nerve, via nerve stimulation, as measured through EMG at the Flexor Digitorum Superficialis muscle

Secondary outcomes

  1. Nerve cross-sectional area (mm^2)

    Time frame: Before and after 4 weeks of training (or just 4 weeks, for controls)

    The area within the visible borders of the nerve, as seen and measured via ultrasound

  2. Maximal strength (kg)

    Time frame: Before and after 4 weeks of training (or just 4 weeks, for controls)

    Maximal handgrip strength using a handgrip dynamometer

  3. Hand motor dexterity (seconds)

    Time frame: Before and after 4 weeks of training (or just 4 weeks, for controls)

    A timed Minnesota manual dexterity task

Sponsors and collaborators

Lead sponsor

Oklahoma State University

Other

Collaborators

  • American College of Sports Medicine - Central States Chapter

Registry information

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Sep 26, 2024
Registry last updated
Sep 26, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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