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NCT Number: NCT05091112

Nerve Composition of Human Lumbar Dorsal Primary Rami and Its Medial Branch

The purpose of the study is to understand the composition of the nerves supplying the facet joints in low back.

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Key information

Conditions

Lumbar Facet Arthrosis Nerve Degeneration Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Woodend Hospital

Aberdeen, Scotland, AB15 6XS, United Kingdom

Location status: Recruiting

Location contact

Santosh Baliga, MbChB, FRCS

CONTACT

Saravana Kanakarajan, MD FRCA

PRINCIPAL_INVESTIGATOR

About this study

After written informed consent, the nerves supplying the facet joints - lumbar dorsal rami and its medial branches, will be harvested when they are exposed during spinal surgery. These nerves will be fixed, washed and further dissected to enable smaller sections. The cut section will be stained and subjected to analysis of overall cross-sectional area and presence of connective tissue sheaths under light microscope.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be aged 18 or over
  • be able to give informed consent
  • scheduled to undergo lumbar spinal surgery

Exclusion criteria

  • Children under 18 years old
  • Vulnerable adults
  • Adults with incapacity
  • Inability to provide informed consent
  • History of previous spinal surgery
  • history of previous RF ablation for low back pain
  • has COVID-19 or displaying symptoms of COVID-19

Treatment and study plan

spinal surgery

Procedure

In participants who undergo elective lumbar spinal surgery and consented for research, the medial branch and dorsal rami will be harvested for histological analysis.

Histology

Other

The harvested nerves will be fixed, cut into smaller sections. Analysis of macroscopic and light microscopic sections will be carried out

Primary outcomes

  1. Nerve Histology

    Time frame: one year

    Percentage of nerves containing more than 50% sensory fibres in lumbar dorsal rami/medial branches to assess whether they are sensory or motor nerves

Study contacts

Contact information is provided by the study sponsor or research team.

Saravanakumar Kanakarajan, MD FRCA

CONTACT

[email protected]

00 44 1224 553237

Sponsors and collaborators

Lead sponsor

University of Aberdeen

Other

Registry information

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Oct 25, 2021
Registry last updated
Dec 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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