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NCT Number: NCT02841982

Quadratus Lumborum Block : Effect on Acute Pain and Quality of Recovery After Laparoscopic Renal Surgery

This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay and incidence of chronic pain,et al. between single-injection QLB(quadratus lumborum block)+ intravenous patient-controlled analgesia (IPCA) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing laparoscopic renal surgeries.

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Key information

Conditions

Laparoscopic Renal Surgery Agnosia Nerve Block Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pain Management Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

17 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Xulei CUI

Beijing, Beijing Municipality, 100730, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-70 yrs
  • American Society of Anesthesiologists physical statusⅠ-Ⅲ
  • Undergo laparoscopic nephrectomy
  • Informed consent

Exclusion criteria

  • A known allergy to the drugs being used
  • Coagulopathy, on anticoagulants
  • Analgesics intake, history of substance abuse
  • Participating in the investigation of another experimental agent
  • Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Treatment and study plan

single-injection QLB(quadratus lumborum block)

Procedure

Inject local anesthetics in between quadratus lumborum and psoas major without continuous local infusion

Philip CX50 Ultrasound Scanner

Device

The curved (C1-5) probe of Philip CX 50 Ultrasound Scanner is used for scan

PAJUNK StimuLong

Device

single dose ropivacaine

Drug
  • 0.6ml/kg 0.5% ropivacaine with 1:200,000 adrenaline.
  • given immediately after the correct position of the tip of the needle has been verified.

Morphine given as IPCA(intravenous patient controlled analgesia)

Drug

bolus: 1.5~2mg, lock time: 10min, 1h limitation: 6~8mg

Primary outcomes

  1. cumulative morphine consumption

    Time frame: within 48 postoperative hours

Secondary outcomes

  1. The pain scores determined by the numeric rating scale (NRS, 0-10)

    Time frame: At 0, 2,4, 8, 12, 24 ,48,72hours after the surgery

  2. nausea and vomiting score

    Time frame: within 24 hours after the surgery

  3. pruritus score

    Time frame: within 24hour after the surgery

  4. ambulation time

    Time frame: within the 7 days after surgery

  5. time of recovery of bowl movement

    Time frame: within the 5 days after surgery

  6. quality of recovery

    Time frame: 3days and 5days after surgery

    use the self-assessment 15 item QoR scale to assess the patient's recovery

  7. Postoperative hospital length of stay

    Time frame: Up to 6 weeks

  8. patient satisfaction with anesthesia

    Time frame: 48 hours after surgery

    use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia

Sponsors and collaborators

Lead sponsor

Cui Xulei

Other

Registry information

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Jul 22, 2016
Registry last updated
May 20, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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