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Completed

NCT Number: NCT05155514

Pulse Wave Velocity and Hemodynamic Response During Anesthesia Induction in Hypertensive Patients

Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness.

In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.

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Key information

Conditions

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Aydın Adnan Menderes University Faculty of Medicine, Department of Anesthesiology and Reanimation

Aydin, 09100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • According to the American Society of Anesthesiologists (ASA), physical condition I-II,
  • Elective otolaryngology surgery with endotracheal intubation planned
  • Patients aged 50 and over

Exclusion criteria

  • Hypersensitivity to drugs
  • Difficult intubation history
  • Diabetes mellitus receiving insulin therapy
  • Chronic renal failure or end-stage renal disease
  • Heart failure (left ventricular ejection fraction ≤30%)
  • Valve disease (moderate to severe)
  • Atrial fibrillation

Treatment and study plan

Mobil-O-Graph PWA

Procedure

After resting in a quiet room preoperatively, blood pressure was measured on the right arm using an oscillometric method.

Primary outcomes

  1. Difference between hemodynamic values

    Time frame: Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation

    The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, ≥20% decrease in preoperative hemodynamic value and/or systolic blood pressure ≤90 mmHg hypotension, ≥20% increased hypertension

Sponsors and collaborators

Lead sponsor

Aydin Adnan Menderes University

Other

Registry information

Official study title

Comparison of the Relationship Between Preoperatively Measured Pulse Wave Velocity and Hemodynamic Changes During Anesthesia Induction in Hypertensive and Normotensive Patients.

Acronym: AS

Important dates

Study start
2018
Primary completion
2019
Study completion
2020
First posted
Dec 13, 2021
Registry last updated
Dec 13, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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