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Completed

NCT Number: NCT07188272

Effect of High-intensity Interval Training Combined With DASH Diet on Arterial Stiffness in Hypertensive Patients

Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide and a major risk factor for morbidity worldwide . It is necessary to reduce the incidence and risk factors of CVD, as physical activity is known to reduce mortality from CVD. Arterial stiffness and hypertension are closely related in pathophysiology. Chronic high blood pressure (BP) can lead to arterial wall damage by mechanical stress, endothelial dysfunction, increased inflammation, oxidative stress, and renin-angiotensin-aldosterone system (RAAS) activation. HIIT has been shown to be equally or even better at stimulating health benefits than moderate-intensity continuous training (MICT) and is considered a time-saving aerobic exercise for reducing arterial stiffness in HTN patients

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Key information

Conditions

Hypertension Arterial Stiffness Cardiovascular Diseases Vascular Diseases

Age range

35 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Waleed Mohamed Abdelmohsen Abdelsalalm

Minya, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Their age< 35 up to 50 years old
  • Both sexes.
  • Controlled HTN ( stage 1,B.P 140-159 mmhg / 90-99 mmhg and stage 2, B.P 160-179 mmhg-100-109 mmhg )
  • Hemodynamic stable. Able to provide informed consent

Exclusion criteria

  • Uncontrolled hypertension.
  • Severe HTN <180/110 mmhg
  • Renal dysfunction
  • Unstable cardiac conditions
  • Severe pulmonary disease that limit exercise
  • Impaired cognition
  • Musculoskeletal problems that made it difficult to do exercise

Treatment and study plan

DASH diet

Dietary Supplement

Eating vegetables, fruits, and whole grains Including fat-free or low-fat dairy products, fish, poultry, beans, nuts, and vegetable oils Limiting foods that are high in saturated fat, such as fatty meats, full-fat dairy products, and tropical oils such as coconut, palm kernel, and palm oils Limiting sugar-sweetened beverages and sweets

High Intensity Interval Training

Procedure

High Intensity Interval Training

Primary outcomes

  1. Pulse Wave Velocity

    Time frame: each week

    normal level 60-100 per minutes

Sponsors and collaborators

Lead sponsor

Deraya University

Other

Registry information

Official study title

Effect of High-intensity Interval Training Combined With DASH Diet on Arterial Stiffness in Hypertensive Patients: a Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Sep 23, 2025
Registry last updated
Jun 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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