Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale

The cause of ischemic stroke remains frequently unknown. In patients with patent foramen ovale (PFO), the link between PFO and Stroke is unclear. The investigators hypothesize that the main mechanism is paradoxical embolism and decided to look for clinically apparent and silent cerebral embolism in patients with a recent pulmonary embolism.

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Key information

Conditions

Recent Stroke Brain Diseases Cardiovascular Abnormalities Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Embolism Embolism and Thrombosis Foramen Ovale, Patent Heart Defects, Congenital Heart Diseases Heart Septal Defects Heart Septal Defects, Atrial Lung Diseases Nervous System Diseases Patent Foramen Ovale Pulmonary Embolism Respiratory Tract Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Army Hospital, Brest, France

About this study

Inclusion criteria

age > 18 years old
confirmed pulmonary embolism
informed consent
social ensured

Exclusion criteria

pregnancy
age < 18 years old
protected major person (in sense of public health)
consent refused
MRI contraindications

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age > 18 years old
confirmed pulmonary embolism
informed consent
social ensured

Exclusion criteria

pregnancy
age < 18 years old
protected major person (in sense of public health)
consent refused
MRI contraindications

Treatment and study plan

Primary outcomes

Incidence of recent ischemic stroke in patients hospitalized for a recent pulmonary embolism with comparison in two groups with and without PFO

Time frame: 7 days

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Is There a Link Between Venous Thromboembolism and Stroke in Patient With Patent Foramen Ovale ? Research for Stroke in Hospitalized Patients With Pulmonary Embolism.

Acronym: EPIC-FOP

Important dates

Study start: 2009
Primary completion: 2015
Study completion: 2017
First posted: Oct 7, 2010
Registry last updated: Jan 12, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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