Puerarin Effects on Alcohol Drinking

This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking. Hypothesis: Short-term treatment with this compound will reduce alcohol self-administration in a simulated natural settings laboratory.

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Key information

Conditions

Alcohol Abuse Alcohol-Related Disorders Alcoholism Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

McLean Hospital, Behavioral Psychopharmacology Research Laboratory

Belmont, Massachusetts, 02478, United States

About this study

Participants will have an opportunity to drink up to 6 beers, plus water and juice, during a 90 minute afternoon drinking session in our simulated apartment room laboratory. Drinking sessions will be conducted in the afternoon after participants take puerarin or placebo for 7 days.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

moderate to heavy alcohol drinkers (20+ drinks per week)

Exclusion criteria

alcohol dependence or treatment-seeking drinkers
other drug abuse or dependence
psychiatric disorders

Treatment and study plan

Puerarin, Placebo

Drug

400 mg, three times a day for 7 days

Other names: Puerarin: NPI-031G, Placebo: Sugar beet extract

Primary outcomes

Amount of Alcohol Consumed

Time frame: During a 90 minute drinking session

Sponsors and collaborators

Lead sponsor

Mclean Hospital

Other

Registry information

Official study title

Puerarin (NPI-031G) Effects on Alcohol Drinking - A Natural Settings Study

Acronym: PAD

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: Mar 3, 2009
Registry last updated: Sep 9, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed