Effectiveness and Safety of Probiotics in Protecting Liver Function

Inclusion criteria

• A history of long-term heavy alcohol consumption, equivalent to ethanol intake ≥40g/day for over 1 year. The conversion formula is: ethanol (g) = volume of ethanol-containing beverage (mL) × ethanol content (%) × 0.8 (specific gravity of ethanol);
• Body Mass Index (BMI) between 18kg/m² and 25kg/m²;
• Voluntarily signed a written informed consent form, agreeing to participate in this study;
• Agreed to comply with the study protocol and restrictions;
• Subjects (including male participants) have no plans for conception from 14 days prior to screening until 6 months after the end of the trial and voluntarily agree to use effective contraception.

Exclusion criteria

• Patients with various types of viral hepatitis, autoimmune liver disease, drug-induced liver damage, vascular liver disease, genetic metabolic liver disease, or primary liver cancer;
• Individuals who have recently consumed substances with similar functions to the tested product, potentially affecting the study results;
• Patients with severe allergies or immune deficiencies;
• Pregnant, breastfeeding, or women with plans for pregnancy;
• Individuals with severe diseases of vital organs such as cardiovascular, pulmonary, hepatic, renal conditions, or those with diabetes, severe thyroid disorders, metabolic diseases, malignant tumors, or severe immune system disorders;
• Individuals who have used antibiotics within the past two weeks;
• Participants who did not comply with the required consumption of the tested product or missed follow-ups, making it impossible to evaluate the effectiveness;
• Other participants deemed unsuitable by the researchers.