Proximal Intestinal Obstruction Syndrome (PIOS) in a Patient With Cystic Fibrosis: A New Syndrome

A case of a patient with cystic fibrosis with bowel obstruction due to a proximal intestinal obstruction syndrome (PIOS) is presented.This syndrome can be diagnosed with the DIOS definition, with the only distinction of a more proximal location in the gastrointestinal tract, such as the stomach, the duodenum, or the jejunum.

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Key information

Conditions

Cystic Fibrosis Bowel Obstruction Congenital, Hereditary, and Neonatal Diseases and Abnormalities Digestive System Diseases Distal Intestinal Obstruction Syndrome Gastrointestinal Diseases Genetic Diseases, Inborn Infant, Newborn, Diseases Intestinal Diseases Intestinal Obstruction Lung Diseases Pancreatic Diseases Respiratory Tract Diseases

Sex eligibility

Male

Study type

Observational

Primary location

Escuela Nacional de Medicina, Tecnologico de Monterrey

Monterrey, Nuevo León, 76140, Mexico

About this study

Distal Intestinal Obstruction Syndrome is a rare complication in cystic fibrosis patients characterized by the accumulation of viscid fecal material, combined with sticky mucous secretions located in the distal ileum, adhered to the intestinal wall. Only few cases have been reported in the literature.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult >18 years
Cystic fibrosis
Bowel obstruction

Exclusion criteria

Pediatric patient <18 years
Unknown cause of bowel obstruction

Treatment and study plan

Diagnostic laparoscopy

Other

A diagnostic laparoscopy was performed where a dilated jejunum was encountered with impaction of fecal content. Surgery was converted to open surgery, where a longitudinal enterotomy of 5 cm after the transition zone was created, evacuating manually the fecal material with mucous secretion.

Primary outcomes

Bowel obstruction in a patient with cystic fibrosis

Time frame: 3-6 days

A 45 year old patient with cystic fibrosis presented with bowel obstruction. Image studies were performed, without identifying a specific cause of the bowel obstruction. The patient was transferred to surgery.

Sponsors and collaborators

Lead sponsor

Tecnologico de Monterrey

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2020
Study completion: 2020
First posted: Nov 3, 2020
Registry last updated: Nov 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed