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NCT Number: NCT05340023

Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension

Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE). CTEPH is evoked in patients with persistent dyspnea. According to international guidelines, symptomatic patients with perfusion defects on lung scan and Pulmonary Hypertension (PH)-likely transthoracic echo (TTE) must be evaluated in Pulmonary Hypertension (PH)-centers with right heart catheterism, to confirm or rule out the presence of precapillary Pulmonary Hypertension (PH), and precise the group of Pulmonary Hypertension (PH).

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Key information

Conditions

Chronic Thromboembolic Pulmonary Hypertension Cardiovascular Diseases Embolism Embolism and Thrombosis Hypertension Hypertension, Pulmonary Lung Diseases Pulmonary Embolism Respiratory Tract Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de SAINT-ETIENNE

Saint-Etienne, 42055, France

Location status: Recruiting

Location contact

Laurent BERTOLETTI, MD PhD

PRINCIPAL_INVESTIGATOR

About this study

However, persistent dyspnea and perfusion defects are frequent after pulmonary embolism (PE), and the accuracy of transthoracic echo (TTE) is not great for precapillary Pulmonary Hypertension (PH).

This study proposed to seek for a specific proteomic pattern in patients admitted for a suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations)
  • Patients who require a right heart catheterization.
  • Patient affiliated or entitled to a social security plan
  • Patient having received informed information about the study informed about the study

Exclusion criteria

  • Patient with a normal perfusion lung scan
  • Person under legal guardianship

Treatment and study plan

Blood sample

Biological

to realize proteomic analysis.

Primary outcomes

  1. Proteomic pattern associated with the diagnosis of Chronic thromboembolic pulmonary hypertension (CTEPH)

    Time frame: Day: 0

    Analysis of the final diagnosis retained for the patient : Chronic thromboembolic pulmonary hypertension (CTEPH) (population of interest), pre-capillary Pulmonary Hypertension (PH) other than Chronic thromboembolic pulmonary hypertension (CTEPH), post-capillary Pulmonary Hypertension (PH), no Pulmonary Hypertension (PH).

Secondary outcomes

  1. Analysis of recording of hemodynamic data at diagnosis

    Time frame: Day: 0

    hemodynamic data : pulmonary vascular resistance, cardiac index, pulmonary arterial pressures

  2. Analysis of recording of hemodynamic data at diagnosis

    Time frame: Day: 0

    hemodynamic data : pulmonary vascular resistance,

  3. Analysis of recording of hemodynamic data at diagnosis

    Time frame: Day: 0

    hemodynamic data : cardiac index

  4. Analysis of recording of hemodynamic data at diagnosis

    Time frame: Day: 0

    hemodynamic data : pulmonary arterial pressures

  5. Analysis of recording of hemodynamic after 6 months of treatment

    Time frame: 6 months

    hemodynamic data : pulmonary vascular resistance,

  6. Analysis of recording of hemodynamic after 6 months of treatment

    Time frame: 6 months

    hemodynamic data : cardiac index

  7. Analysis of recording of hemodynamic data at diagnosis and at death

    Time frame: 6 months

    hemodynamic data : pulmonary arterial pressures

Study contacts

Contact information is provided by the study sponsor or research team.

Carine LABRUYERE

CONTACT

[email protected]

(0)477120826 ext. +33

Laurent BERTOLETTI, MD PhD

CONTACT

[email protected]

(0)477127770 ext. +33

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Official study title

Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension : PROTEO-CTEPH Study.

Acronym: PROTEO-CTEPH

Important dates

Study start
2022
Primary completion
2026
Study completion
2027
First posted
Apr 21, 2022
Registry last updated
Nov 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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