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Completed

NCT Number: NCT01358305

Protein Blends (Soy, Whey and Casein) for Muscle Synthesis

Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow). This intermediate rate may allow soy protein to have an extended window of muscle protein synthesis that has not been monitored in previous studies. While most of the sports nutrition "recovery" products are dairy-based protein blends (high in branched-chain amino acids), soy protein offers additional benefits that can make an important contribution to these types of sports nutrition products. Soy protein contains approximately 300% more arginine and 30% more glutamine compared to whey protein and these two amino acids may bring additional benefits (immunity and hydration, respectively) to athletes. A "blend" of high-quality proteins (soy and dairy) may be the optimal sports nutrition product for athletes to consume following training.

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Key information

Conditions

Muscle Synthesis

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UTMB General Clinical Research Center, located in the John Sealy Hospital

Galveston, Texas, 77555, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion:

  • Age 18-35 yrs
  • Stable body weight for at least 1 year

Exclusion criteria

will be:

  • Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
  • Significant heart, liver, kidney, blood, or respiratory disease
  • Peripheral vascular disease
  • Diabetes mellitus or other untreated endocrine disease
  • Active cancer (all groups) and history of cancer (groups potentially randomizable to rapamycin)
  • Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes)
  • Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
  • Alcohol or drug abuse
  • Tobacco use (smoking or chewing)
  • Malnutrition (BMI < 20 kg/m2, hypoalbuminemia, and/or hypotransferrinemia)
  • Obesity (BMI > 30 kg/m2)
  • Low hemoglobin levels (below normal values)
  • Food allergies
  • Taking dietary supplements such as green tea, etc.
  • Currently on a high-soy diet (consuming >2 servings of soy per day)

Treatment and study plan

Protein Blend

Other

Single intake of approximately 20 grams of total protein

Primary outcomes

  1. Muscle Protein Synthesis or Fractional synthesis rate (FSR)

    Time frame: baseline, 3 hours, 5 hours

    The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-[ring-13C6]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment.

Secondary outcomes

  1. oxidative and inflammatory markers

    Time frame: baseline, 3 hours, 5 hours

    Proteins will be assessed that are markers of oxidative damage and inflammation (NFkB, IL-1, IL-6) and proteolysis (MuRF, MAFBx).

  2. Phosphorylation of protein in muscle protein signaling pathways

    Time frame: baseline, 3 hours, 5 hours

    Phosphorylation of mTOR, 4E-BP1, S6K1, S6, and eEF2 will be measured using Western blot techniques as previously described.

Sponsors and collaborators

Lead sponsor

DuPont Nutrition and Health

Industry

Collaborators

  • University of Texas

Registry information

Official study title

A Randomized, Controlled Double Blind Acute Study: Effects of Protein Blends on Muscle Protein Synthesis and Breakdown

Important dates

Study start
2011
Primary completion
2012
Study completion
2013
First posted
May 23, 2011
Registry last updated
Oct 7, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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