Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia

Serial quantitative measurements of plasma pro-endothelin-1 concentrations in very preterm infants. Comparing pro-endothelin-1 with established clinical indices of bronchopulmonary dysplasia (BPD). Hypothesis: Pulmonary-vascular remodeling in infants developing BPD is directly related to circulating pro-endothelin-1, which therefore serves as surrogate marker of BPD.

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Key information

Conditions

Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities Infant, Newborn, Diseases Infant, Premature, Diseases Lung Diseases Lung Injury Respiratory Tract Diseases Ventilator-Induced Lung Injury

Age range

2 week–4 month

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Zurich, Division of Neonatology

Zurich, Canton of Zurich, 8091, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Very preterm infants born before 32 weeks gestational age

Exclusion criteria

Severe fetal malformation, congenital heart defect, inborn syndrome, cardiomyopathy, fetal hydrops

Treatment and study plan

Blood sampling

Other

blood sampling

Primary outcomes

duration of supplemental oxygen requirement

Time frame: 36 weeks postmenstrual age

Bronchopulmonary dysplasia

Secondary outcomes

duration of respiratory pressure support

Time frame: during hospitalisation

respiratory pressure support either mechanical and/or nCPAP (days)

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

University Children's Hospital Basel

Registry information

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2013
First posted: Jul 19, 2012
Registry last updated: May 10, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed