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Completed

NCT Number: NCT03752450

Prospective Data Analysis of the Development of Hypernatremia in Intensive Care Unit

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and salt balance or renal replacement therapy is lacking. This study aims to provide better insight in the development and recovery of hypernatremia through the collection of detailed information on the input and output of fluids and salts in a larger group of patients than studied before.

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Key information

Conditions

Hypernatremia Metabolic Diseases Nutritional and Metabolic Diseases Water-Electrolyte Imbalance

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Catharina Hospital Eindhoven

Eindhoven, North Brabant, 5623 EJ, Netherlands

About this study

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. The main mechanism is an imbalance between sodium and total body water. Consequently, this poses multiple factors to play a role in the development of hypernatremia. multifactorial. Previous studies focused on predictors in the development of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and salt balance or renal replacement therapy is lacking. Few studies investigated the recovery of hypernatremia, which showed that correction of hypernatremia can reduce the associated mortality risk.

This study aims to provide better insight in the development and recovery of hypernatremia through the collection of detailed information on the input and output of fluids and salts in a larger group of patients than studied before.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults >17 years old
  • Admitted >48 hours in ICU

Exclusion criteria

  • Expected discharge same day as day of inclusion

Treatment and study plan

Primary outcomes

  1. Development of hypernatremia

    Time frame: During ICU admission

    Serum sodium levels >145mmol/L

  2. Recovery of hypernatremia

    Time frame: During ICU admission

    Serum sodium levels returning back to levels below 146mmol/L

Secondary outcomes

  1. Mortality

    Time frame: During ICU admission as well as during hospital admission

    Patient did or did not pass away.

  2. Length of stay

    Time frame: Admission in ICU as well as in hospital

    Number of days of admission

Sponsors and collaborators

Lead sponsor

Catharina Ziekenhuis Eindhoven

Other

Registry information

Official study title

Insight in the Development and Recovery of Hypernatremia in Critically Ill Patients.

Acronym: HYPNIC

Important dates

Study start
2018
Primary completion
2018
Study completion
2019
First posted
Nov 26, 2018
Registry last updated
Apr 12, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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