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OpenTrials
Completed

NCT Number: NCT00744159

Prospective Comparison of Immunological Benefit of Laparoscopic Colectomy

This study aimed to clarify existence of immunological benefit of laparoscopic colon cancer surgery compared to open colon surgery.

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Key information

Conditions

Immunity Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsung Medical Center, Department of surgery

Seoul, South Korea

About this study

Patients with clinical stage Ⅲ left colon and upper rectal cancer were prospectively assigned to undergo LC (n=35) or OC (n=39). Factors related to cellular immunity of host (total lymphocyte count, CD4 lymphocyte, CD8 lymphocyte, CD4/CD8 ratio, HLA-DR expression on monocyte (mHLA-DR)) were examined preoperatively, on the 1st day of operation (POD1) and the 5th day of operation (POD5).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Biopsy proven of colon cancer
  • Preoperatively suspected as clinical stage III colon cancer
  • Lesion located Descending colon, sigmoid colon and upper rectal cancer

Exclusion criteria

  • Could not perform curative resection
  • Intestinal obstruction, perforation, intra-abdominal abscess
  • Severe medical illness
  • Immunopathy

Treatment and study plan

Primary outcomes

  1. Immune factors

    Time frame: post OP 5th day

Secondary outcomes

  1. Post-operative complications

    Time frame: POD 7th days

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Prospective Comparative Study of Immunological Benefit Between Laparoscopic Colectomy and Open Colectomy

Important dates

Study start
2006
Primary completion
2007
Study completion
2007
First posted
Aug 29, 2008
Registry last updated
Aug 29, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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