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NCT Number: NCT07196917

Prospective Cohort of Integrated Traditional Chinese and Western Medicine in China

To further explore the application prospects of integrated Traditional Chinese and Western medicine in chronic disease prevention and control and health management, this study intends to establish a large, prospective, integrated Traditional Chinese and Western medicine cohort in Hubei Province. This study will conduct long-term follow-up and multi-dimensional data collection to systematically reveal the associations between Traditional Chinese Medicine (TCM) constitution types and chronic diseases, the aging process, and multi-morbidity, thereby developing an integrated health management strategy with local characteristics. This study will fill the current gap in systematic evidence linking TCM constitutions to the prevalence of modern diseases, providing a solid demographic and biological foundation for the integrated development of Traditional Chinese and Western medicine. It will also contribute to meeting the needs for early disease warning, early intervention, and personalized care under the "Healthy China" strategic goal.

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Key information

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age: Participants aged 30 to 74 years

Physical Functionality: Free from severe physical disabilities impacting mobility or communication, with preserved ability to comprehend and respond to study procedures

Informed Consent: Capable of providing written informed consent voluntarily after receiving full study disclosure

Exclusion criteria

Residents living in functional areas (e.g., work sheds, military units, student dormitories, nursing homes, etc.)

Individuals unable to communicate normally

Treatment and study plan

Primary outcomes

  1. Prospective Cohort of Integrated Traditional Chinese and Western Medicine in China

    Time frame: From enrollment to the 10-year follow-up

  2. Incidence of major chronic diseases (coronary heart disease, stroke, diabetes, COPD, lung cancer, colorectal cancer, gastric cancer, liver cancer, and esophageal cancer)

    Time frame: From baseline (enrollment) to 10-year follow-up Measurement Tool: Standardized physician-adjudicated diagnosis based on ICD-10 codes, confirmed through hospital electronic medical records and disease registries

Secondary outcomes

  1. All-cause mortality

    Time frame: From baseline to 10-year follow-up

    Time Frame: From baseline to 10-year follow-up Measurement Tool: Death registry linkage and hospital records Unit of Measure: Mortality rate per 1,000 person-years

Other outcomes

  1. Cause-specific mortality (cardiovascular, cancer, respiratory, metabolic)

    Time frame: From baseline to 10-year follow-up

    Time Frame: From baseline to 10-year follow-up Measurement Tool: Death registry and ICD-10 coded cause of death Unit of Measure: Mortality rate per 1,000 person-years

  2. Prevalence and progression of multimorbidity (≥2 chronic conditions)

    Time frame: Baseline to 10-year follow-up

    Time Frame: Baseline to 10-year follow-up Measurement Tool: Questionnaire survey and physician-adjudicated diagnosis using ICD-10 Unit of Measure: % of participants with multimorbidity

Sponsors and collaborators

Lead sponsor

Huazhong University of Science and Technology

Other

Collaborators

  • Hubei College of Traditional Chinese Medicine
  • Hubei Hospital of Traditional Chinese Medicine
  • Hubei Provincial Center for Disease Control and Prevention
  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Wuhan Center for Disease Control and Prevention

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Sep 29, 2025
Registry last updated
Oct 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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