Research on the Application and Mechanism of New Biological Probes in Biomedicine

Fluorescence is one of the most commonly used research and detection techniques in the field of biomedical science. The characteristics of fluorescent probe directly affect the performance and application of fluorescence analysis and imaging. Aggregation-Caused Quenching has limited the application of traditional fluorescent probes to some extent. This project intends to systematically evaluate the detection efficiency of new methods through the detection of biomarkers in clinical samples and the comparison with the detection methods of traditional biomarkers, so as to provide theoretical and experimental basis for the establishment of fast and simple biomarker detection technologies with new biological probes.

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Key information

Conditions

Tumors Blood Diseases Cardiovascular Diseases Communicable Diseases Digestive System Diseases Disease Attributes Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hematologic Diseases Hemic and Lymphatic Diseases Immune System Diseases Infections Infectious Diseases Male Urogenital Diseases Metabolic Diseases Neoplasms Nervous System Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory System Diseases Respiratory Tract Diseases Urinary System Diseases Urogenital Diseases Urologic Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Nanfang Hospital

Guangzhou, Guangdong, 510515, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Sign the informed consent form voluntarily.
Age 18-70 years old.
High expression (positive) group: The results of multiple laboratory tests indicate that the marker is higher than the normal range.
Low expression (negative) healthy volunteer group: those with no underlying diseases and no abnormalities in the physical examination.
Have routine examination to check the remaining body fluid samples, and the body fluid samples are not contaminated.

Exclusion criteria

Accompanied by other inflammations.
The data of the subject is not complete, or the collection of cases is incomplete due to other reasons.
The researcher judged that it was not suitable to participate in this research.

Treatment and study plan

No intervention

Diagnostic Test

No intervention

Primary outcomes

signal intensity of the probes

Time frame: one day

Sponsors and collaborators

Lead sponsor

Nanfang Hospital, Southern Medical University

Other

Registry information

Important dates

Study start: 2021
Primary completion: 2022
Study completion: 2022
First posted: Jul 27, 2021
Registry last updated: Aug 22, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed