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NCT Number: NCT07156955

Proprioceptive Error Correction for Post-Stroke Upper Limb Rehabilitation

The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs. This study is designed to test proprioceptive error compensation techniques in stroke patients.

The human nervous system often receives mismatched information from vision and proprioception during upper limb control, resulting in conflicting sensory inputs that limit the effectiveness of motor learning. In other words, real-time sensory feedback - a critical component of motor learning in the nervous system - is not reliably delivered. Therefore, this study seeks to resolve sensory conflicts by providing additional sensory information through electrical stimulation, with the goal of dramatically improving the effectiveness of motor learning.

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Key information

Conditions

Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Proprioception Stroke Vascular Diseases

Age range

19 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shinchon Severance Rehabilitation Hospital

Seoul, 03722, South Korea

Location status: Recruiting

Location contact

HyunHee Lim

CONTACT

[email protected]

+82-10-3342-1879

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with ischemic or hemorrhagic stroke
  • Stroke confirmed by CT or MRI
  • Stroke patients with proprioceptive sensory deficits
  • Chronic stroke patients with onset at least 3 months prior
  • Able to voluntarily flex and extend the elbow joint
  • Age 19 years or older
  • Provide written informed consent (participant or legal representative)

Exclusion criteria

  • Severe pain during elbow joint movement
  • Elbow joint contracture, spasticity, ataxia, musculoskeletal disorders, fractures, - non-healing ulcers, or open wounds
  • Progressive or unstable stroke
  • Presence of unilateral neglect
  • Coexisting severe neurological disorders
  • Major psychiatric disorders such as major depressive disorder, schizophrenia, bipolar disorder, or dementia Presence of a pacemaker

Treatment and study plan

Electrical stimulation cue

Behavioral

A single 30-minute session is provided. Electrodes are attached to the cubital fossa, and stimulation is delivered at a frequency that increases up to 70 Hz as the elbow joint approaches the target angle. Target angles are set between 0 degrees and 120 degrees, based on each participant's available range of motion determined during the initial assessment. Participants adjust their elbow joint angle to match the provided target angle using feedback from the electrical stimulation. When the elbow joint angle matches the target angle, the maximum frequency is applied to the cubital fossa. Participants match their elbow joint angle to the target angle based on the given frequency.

Visual stimulation cue

Behavioral

A single 30-minute session is provided. The difference between the current elbow joint angle and the pre-set target angle is displayed on a screen using two colored needles (a red needle for the target angle and a black needle for the current elbow joint angle). The target angle is set within each participant's available range of motion based on the initial assessment. Participants continue the intervention by adjusting their elbow angle using the visual feedback. When the elbow joint angle matches the target angle, the two needles overlap. Based on this visual cue, participants adjust their elbow joint angle to match the target angle.

No cue

Behavioral

A single 30-minute session is provided. The target angle is determined within each participant's available range of motion based on the initial assessment. Throughout the session, participants receive verbal feedback from the assessor and adjust their elbow joint angle accordingly to match the target angle.

Primary outcomes

  1. Improvement in upper limb motor function

    Time frame: 6 visits over 3 weeks

    Upper limb motor function will be evaluated using standardized clinical scales such as the Fugl-Meyer Assessment and proprioceptive accuracy tests.

    0 indicates severe movement limitation, while a score of 66 reflects normal motor function of upper limb.

    Participants will undergo evaluations and treatment during six visits over approximately three weeks.

Secondary outcomes

  1. Proprioceptive accuracy

    Time frame: Baseline before intervention and immediately after the 30-minute training session

    Assessment of improvements in upper limb motor function and proprioceptive accuracy after applying sensory error correction techniques in stroke patients. Motor performance will be evaluated using standardized clinical scales and joint position sense tests. The expected outcome measures are a reduction of the error angle relative to the target angle to within ±5 degrees.

Study contacts

Contact information is provided by the study sponsor or research team.

Hyunhee Lim

CONTACT

[email protected]

+82-10-3342-1879

June Seung Lee, Graduate student

CONTACT

[email protected]

+82-10 - 2087 - 0016

Sponsors and collaborators

Lead sponsor

Sungkyunkwan University

Other

Registry information

Official study title

Proprioceptive Error Correction Technique Development to Promote Post-stroke Upper Limbs Motor Rehabilitation

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Sep 5, 2025
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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