Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes

Inclusion criteria

• Age 18+
• Smoke an average of at least five cigarettes per day for at least 1 year
• Breath CO levels > 8 ppm (if ≤ 8 ppm, then NicAlert Strip > 2)

Exclusion criteria

• Intention to quit smoking in the next 30 days
• Currently seeking treatment for smoking cessation
• Currently using nicotine replacement therapies or other pharmacotherapies as cessation aid (intermittent use acceptable)
• A quit attempt in the past 30 days resulting in greater than 3 days of abstinence
• Using other tobacco products more than 9 days in the past 30 days
• Significant unstable medical conditions (Any significant change in a serious medical condition occurring during the past 3 months including, cardiovascular disease, COPD, and cancer, as determined by the licensed medical professional at each site)
• Significant unstable psychiatric conditions (Any significant change in psychiatric symptoms during the past 3 months as determined by the licensed medical professional at each site)
• Schizophrenia and schizoaffective disorder
• Psychiatric medication changes in the past 3 months
• Positive toxicology screen for any of the following drugs: cocaine, opiates, methadone, benzodiazepines, barbiturates, amphetamines, methamphetamines, and PCP

• Marijuana will be tested for but will not be an exclusionary criterion.
• Participants with valid prescriptions for opiates, benzodiazepines, barbiturates, amphetamines or methadone will not be excluded.
• Participants failing the toxicology screen will be allowed to re-screen once.
• Blood alcohol level > 0.01

a. Participants failing the blood alcohol screen will be allowed to re-screen once.

• Binge drinking alcohol (more than 9 days in the past 30 days, 4/5 in a 2 hour period(female/male))
• Pregnant or breastfeeding
• Smoking 'roll your own cigarettes' exclusively
• Currently taking anticonvulsant medication
• CO reading >80 ppm
• Systolic BP greater than or equal to 160

a. Participants failing for blood pressure will be allowed to re-screen once.

• Diastolic BP greater than or equal to 100

a. Participants failing for blood pressure will be allowed to re-screen once.

• Systolic BP below 90

a. Participants failing for blood pressure will be allowed to re-screen once.

• Diastolic BP below 50

a. Participants failing for blood pressure will be allowed to re-screen once.

• Heart rate greater than or equal to 115bpm

a. Participants failing for heart rate will be allowed to re-screen once.

• Heart rate lower than 45bpm

a. Participants failing for heart rate will be allowed to re-screen once.

• Indicating any suicidal ideation in the past month or suicide attempts in the past 10 years
• Inability to independently read and comprehend the consent form and other written study materials and measures
• Having participated in a research study during the past three months in which the participant:

• Smoked a cigarette that was not his/her usual brand cigarette for more than one day
• Used any tobacco products beyond normal use for more than one day
• Used any nicotine replacement products or smoking cessation medications for more than one day