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NCT Number: NCT07293338

Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy

The goal of this observational study is to learn about the long-term prognostic of coronary microvascular dysfuction in Patients with Dilated Cardiomyopathy.

The main question it aims to answer is: Does the coronary microvascular dysfunction impact the outcomes in Patients with Dilated Cardiomyopathy.

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Key information

Conditions

Dilated Cardiomyopathy (DCM) Cardiomegaly Cardiomyopathies Cardiomyopathy, Dilated Cardiovascular Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Heart Diseases Laminopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The second affiliated hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310009, China

Location status: Recruiting

Location contact

Jun Jiang

CONTACT

[email protected]

+86 15657125311

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Dilated cardiomyopathy comfirmed by echocardiography: LVDd > 55 mm in men or > 50 mm in women.
  • Clinically evident congestive heart failure: Compatible symptoms and signs, and BNP ≥ 35 pg/mL or NT-proBNP ≥ 125 pg/mL, and LV systolic dysfunction defined by LVEF < 45 %.
  • Coronary angiography showing stenosis ≤ 50 % in all major epicardial vessels.

Exclusion criteria

  • Patients with coronary artery disease, hypertensive heart disease, rheumatic valvular heart disease, myocarditis, and other secondary cardiomyopathies.
  • poor angiographic image quality

Treatment and study plan

Coronary Angiography

Procedure

Patients should undergo coronary angiography to confirm the absence of significant coronary stenosis. Angio-IMR was calculated based on the angiography.

Primary outcomes

  1. Major adverse cardiac events

    Time frame: At 5-year follow-up

    A composite of cardiac death, hospitalization for heart failure, heart transplantation, and device implantation

Study contacts

Contact information is provided by the study sponsor or research team.

Jun Jiang, MD

CONTACT

[email protected]

+86 15657125311

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Dec 19, 2025
Registry last updated
Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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