Prognostic Value of Progesterone for In Vitro Fertilization (IVF) Outcome

This observational study attempts to investigate the potential role of serum progesterone levels on the day of hCG administration (thus, the end of the follicular phase) on the probability of pregnancy, in patients undergoing IVF with the use of GnRH antagonists and recombinant gonadotrophins.

There has been evidence, that increased serum levels of progesterone are associated with a decreased probability of pregnancy after IVF.

This study will attempt to explore the role of progesterone on the outcome of IVF, by closely monitoring its levels during the late follicular phase.

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Key information

Conditions

Subfertility Genital Diseases Infertility Urogenital Diseases

Age range

18 year–39 year

Sex eligibility

Female

Study type

Observational

Primary location

Unit for Human Reproduction, 1st Dept. of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki

Thessaloniki, Greece

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age < 40 years
Basal FSH < 12 IU/L
Basal P < 1.6 ng/mL

Exclusion criteria

Presence of cystic formations at the ovaries during the basal ultrasound scan (prior the initiation of stimulation)
Women with polycystic ovaries syndrome (PCOS)
Women with Stage III-IV Endometriosis
Women with a pathological condition of the adrenal glands

Treatment and study plan

Primary outcomes

Clinical pregnancy, defined as ultrasound evidence of fetal heart activity at 6-8 weeks of gestation

Time frame: At 6-8 weeks of gestation

Secondary outcomes

Pregnancy (defined as a b-hCG> 25 IU/L)

Time frame: 12 days after embryo transfer

Sponsors and collaborators

Lead sponsor

Aristotle University Of Thessaloniki

Other

Registry information

Official study title

The Effect of Serum Progesterone Levels on the Day of hCG Administration on the Probability of Pregnancy in Patients Treated by IVF Using GnRH Antagonists and Recombinant Gonadotrophins

Acronym: PROG2

Important dates

Study start: 2009
Primary completion: 2013
Study completion: 2013
First posted: Feb 11, 2010
Registry last updated: Oct 18, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed